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Titolo:
Fluid-attenuated inversion recovery magnetic resonance imaging detects cortical and juxtacortical multiple sclerosis lesions
Autore:
Bakshi, R; Ariyaratana, S; Benedict, RHB; Jacobs, L;
Indirizzi:
SUNY Buffalo, Sch Med & Biomed Sci, Kaleida Hlth, Dept Neurol, Buffalo, NY14260 USA SUNY Buffalo Buffalo NY USA 14260 Hlth, Dept Neurol, Buffalo, NY14260 USA SUNY Buffalo, Sch Med & Biomed Sci, Kaleida Hlth, Dept Imaging Serv, Buffalo, NY 14260 USA SUNY Buffalo Buffalo NY USA 14260 ept Imaging Serv, Buffalo, NY 14260 USA SUNY Buffalo, Sch Med & Biomed Sci, Kaleida Hlth, Dept Psychiat, Buffalo, NY 14260 USA SUNY Buffalo Buffalo NY USA 14260 h, Dept Psychiat, Buffalo, NY 14260 USA SUNY Buffalo, Sch Med & Biomed Sci, Kaleida Hlth, Dept Psychol, Buffalo, NY 14260 USA SUNY Buffalo Buffalo NY USA 14260 th, Dept Psychol, Buffalo, NY 14260 USA
Titolo Testata:
ARCHIVES OF NEUROLOGY
fascicolo: 5, volume: 58, anno: 2001,
pagine: 742 - 748
SICI:
0003-9942(200105)58:5<742:FIRMRI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
APPEARING WHITE-MATTER; CONVENTIONAL SPIN-ECHO; FLAIR PULSE SEQUENCES; MR-IMAGES; BRAIN ATROPHY; WALLERIAN DEGENERATION; COGNITIVE IMPAIRMENT; DEPRESSION; DISEASE; MS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Bakshi, R Buffalo Gen Hosp, Neurosci Ctr, E-2,100 High St, Buffalo, NY 14203 USA Buffalo Gen Hosp E-2,100 High St Buffalo NY USA 14203 14203 USA
Citazione:
R. Bakshi et al., "Fluid-attenuated inversion recovery magnetic resonance imaging detects cortical and juxtacortical multiple sclerosis lesions", ARCH NEUROL, 58(5), 2001, pp. 742-748

Abstract

Background: Autopsy studies showed cortical and juxtacortical multiple sclerosis (MS) plaques. Fluid-attenuated inversion recovery (FLAIR) is an advanced magnetic resonance imaging sequence that reveals tissue T2 prolongation with cerebrospinal fluid suppression, allowing detection of superficial brain lesions. Objectives: To assess FLAIR, T1-weighted, and T2-weighted images for detecting lesions in or near the cerebral cortex in patients with MS and to explore the relation between cortical lesions and cortical atrophy. Design, Setting, and Patients: Cross-sectional study in a university MS clinic of 84 patients with MS and 66 age-matched healthy controls receiving 1.5-T fast FLAIR, T2-weighted, and T1-weighted images. Main Outcome Measures: Regional cortical atrophy was rated vs controls. Cortical and juxtacortical lesions were ovoid hyperintensities involving the cortex and/or gray-white junction. Results: A total of 810 cortical and juxtacortical lesions were seen by FLAIR in patients (mean, 9.6 perpatient), most. commonly ill the superior frontal lobe. Cortical and juxtacortical lesions were identified in 72 patients and 6 controls. Fourteen percent of cortical and juxtacortical lesions were seen on T1-weighted images and 26% were seen on T2-weighted images. Morecortical and juxtacortical lesions were present in secondary progressive disease than relapsing-remitting disease. The total number of cortical and juxtacortical lesions correlated significantly with disease duration and theregional number correlated with the degree of regional atrophy. After taking into account noncortical (white matter) lesions, only the cortical and juxtacortical lesion count predicted atrophy in that region. Conclusions: FLAIR can detect many cortical and juxtacortical lesions in MS, which were appreciated previously in autopsy studies but usually missed by magnetic resonance imaging during life. Cortical and juxtacortical plaque formation may contribute to cortical atrophy in MS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 17:25:44