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Titolo:
Lymph node necrosis in systemic lupus erythematosus - A histopathological and immunohistochemical study of four cases
Autore:
Kojima, M; Nakamura, S; Itoh, H; Yoshida, K; Suchi, T; Masawa, N;
Indirizzi:
Dokkyo Univ, Sch Med, Dept Pathol, Mibu, Tochigi 3210923, Japan Dokkyo Univ Mibu Tochigi Japan 3210923 thol, Mibu, Tochigi 3210923, Japan Aichi Canc Ctr Hosp, Dept Pathol & Genet, Nagoya, Aichi 464, Japan Aichi Canc Ctr Hosp Nagoya Aichi Japan 464 enet, Nagoya, Aichi 464, Japan Maebashi Red Cross Hosp, Dept Pathol, Maebashi, Gumma, Japan Maebashi Red Cross Hosp Maebashi Gumma Japan hol, Maebashi, Gumma, Japan Maebashi Red Cross Hosp, Clin Labs, Maebashi, Gumma, Japan Maebashi Red Cross Hosp Maebashi Gumma Japan abs, Maebashi, Gumma, Japan Kiryu Welf Gen Hosp, Dept Pathol, Kiryu, Gumma, Japan Kiryu Welf Gen HospKiryu Gumma Japan , Dept Pathol, Kiryu, Gumma, Japan Kiryu Welf Gen Hosp, Clin Labs, Kiryu, Gumma, Japan Kiryu Welf Gen Hosp Kiryu Gumma Japan sp, Clin Labs, Kiryu, Gumma, Japan
Titolo Testata:
APMIS
fascicolo: 2, volume: 109, anno: 2001,
pagine: 141 - 146
SICI:
0903-4641(200102)109:2<141:LNNISL>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
HISTIOCYTIC NECROTIZING LYMPHADENITIS; CYTOTOXIC T-CELLS; HEMORRHAGE; APOPTOSIS;
Keywords:
systemic lupus erythematosus; lymph node necrosis; necrotizing angitis; immune complex vasculitis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Kojima, M Dokkyo Univ, Sch Med, Dept Pathol, Mibu, Tochigi 3210923, Japan Dokkyo Univ Mibu Tochigi Japan 3210923 , Tochigi 3210923, Japan
Citazione:
M. Kojima et al., "Lymph node necrosis in systemic lupus erythematosus - A histopathological and immunohistochemical study of four cases", APMIS, 109(2), 2001, pp. 141-146

Abstract

The lymph node lesions of lupus lymphadenitis are characterized by necrosis sometimes accompanied by hematoxylin bodies, but only a few immunohistological analyses of this unique lesion have been reported. In this study we investigated the immunopathogenesis of these lesions. Lymph node specimens from four patients were analyzed immunohistochemically by applying recently developed monoclonal antibodies to immunocompetent cells. Necrosis occupiedalmost the entire lymph node in two cases (extensive type), whereas small foci of necrosis were found in the paracortex in the remaining two (localized type). No hematoxylin body formation was detected in any of the samples. Necrosis of the small muscular arteries, arterioles and venules was seen in the necrotic areas in all four cases. In one case of the localized type, necrotizing angitis was seen in a few arterioles and venules in the non-necrotic area. By immunohistology, amorphous depositions of immunoglobulins and C3 were demonstrated in the walls of the arterioles and venules in two cases. Our findings indicate that vasculitis due to local deposition of immune complexes in the blood vessels may play an important role in the pathogenesis of necrosis in lupus lymphadenitis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 18:59:41