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Titolo:
Water-soluble organotellurium compounds inhibit thioredoxin reductase and the growth of human cancer cells
Autore:
Engman, L; Kanda, T; Gallegos, A; Williams, R; Powis, G;
Indirizzi:
Univ Uppsala, Inst Chem, Dept Organ Chem, S-75121 Uppsala, Sweden Univ Uppsala Uppsala Sweden S-75121 Organ Chem, S-75121 Uppsala, Sweden Univ Arizona, Arizona Canc Ctr, Tucson, AZ 85724 USA Univ Arizona Tucson AZ USA 85724 , Arizona Canc Ctr, Tucson, AZ 85724 USA
Titolo Testata:
ANTI-CANCER DRUG DESIGN
fascicolo: 5, volume: 15, anno: 2000,
pagine: 323 - 330
SICI:
0266-9536(200010)15:5<323:WOCITR>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA-BINDING ACTIVITY; REDOX REGULATION; MESSENGER-RNA; HUMAN TUMORS; EXPRESSION; SELENOCYSTEINE; CLONING; PURIFICATION; COEXPRESSION; SEQUENCE;
Keywords:
thioredoxin reductase; water-soluble organotellurium compounds; antitumor activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Engman, L Univ Uppsala, Inst Chem, Dept Organ Chem, Box 531, S-75121 Uppsala, Sweden Univ Uppsala Box 531 Uppsala Sweden S-75121 121 Uppsala, Sweden
Citazione:
L. Engman et al., "Water-soluble organotellurium compounds inhibit thioredoxin reductase and the growth of human cancer cells", ANTI-CAN DR, 15(5), 2000, pp. 323-330

Abstract

The thioredoxin system (NADPH, thioredoxin reductase/ thioredoxin) is important for cancer cell growth and inhibition of apoptosis and presents an attractive target for anticancer drug development. Thioredoxin reductase is aselenocysteine-containing flavoenzyme that catalyzes the reduction of oxidized thioredoxin, This enzyme could therefore be used for regulating the activity of the thioredoxin system. Water-soluble organotellurium compounds of the diaryl telluride, alkyl aryl telluride and dialkyl telluride type, carrying sulfopropyl groups, were found to be the most efficient tellurium-based inhibitors of thioredoxin reductase ever tested. Some of the compounds inhibited the enzyme at submicromolar levels. The compounds also inhibited the growth of MCF-7 and MT-29 human cancer cells in culture at the 5-10 muMlevel but their hydrophilicity seemed to restrict cellular uptake.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 01:19:09