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Titolo:
Design issues for conducting cost-effectiveness analyses alongside clinical trials
Autore:
Ramsey, SD; McIntosh, M; Sullivan, SD;
Indirizzi:
Univ Washington, Dept Med, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ton, Dept Med, Seattle, WA 98195 USA Univ Washington, Dept Pharm, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 n, Dept Pharm, Seattle, WA 98195 USA Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr Seattle WA USA 98109 , Seattle, WA 98109 USA Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Hlth Serv, Seattle, WA 98195 USA
Titolo Testata:
ANNUAL REVIEW OF PUBLIC HEALTH
, volume: 22, anno: 2001,
pagine: 129 - 141
SICI:
0163-7525(2001)22:<129:DIFCCA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
EFFECTIVENESS RATIOS; CONFIDENCE-INTERVALS; ECONOMIC-ANALYSIS; GUIDELINES;
Keywords:
economic; randomized; quality of life; power estimation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Ramsey, SD Univ Washington, Dept Med, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ed, Seattle, WA 98195 USA
Citazione:
S.D. Ramsey et al., "Design issues for conducting cost-effectiveness analyses alongside clinical trials", ANN R PUB H, 22, 2001, pp. 129-141

Abstract

In response to rising demands for timely economic data on new medical technologies, cost-effectiveness studies are increasingly being conducted alongside clinical trials. Because of the historical differences in perspective and methods between cost-effectiveness studies and clinical trials, the design phase of these hybrid trials requires special consideration. Cost-effectiveness studies require more comprehensive evaluations of outcomes than the endpoints typically measured in clinical trials. Often, these comprehensive outcome measures (such as quality of life) prove useful for interpretingthe other endpoints measured in the trial, as well as for estimating the cost-effectiveness of the intervention. In this manuscript, we discuss several aspects related to the design of joint clinical/economic trials, including study perspective, hypothesis testing, sample size estimation, and methods for collecting cost and outcome data. We also discuss issues that may limit the external validity of the cost-effectiveness results of these trials. Many potential threats to external validity can be successfully addressedif they are identified and accounted for in the design phase of the study.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:44:47