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Titolo:
Preoperative chemotherapy for lung cancer does not increase surgical morbidity
Autore:
Siegenthaler, MP; Pisters, KM; Merriman, KW; Roth, JA; Swisher, SG; Walsh, GL; Vaporciyan, AA; Smythe, WR; Putnam, JB;
Indirizzi:
Univ Texas, MD Anderson Canc Ctr, Dept Thorac & Cardiovasc Surg, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 & Cardiovasc Surg, Houston, TX 77030 USA Univ Texas, MD Anderson Canc Ctr, Dept Thorac Oncol, Houston, TX 77030 USAUniv Texas Houston TX USA 77030 Dept Thorac Oncol, Houston, TX 77030 USA
Titolo Testata:
ANNALS OF THORACIC SURGERY
fascicolo: 4, volume: 71, anno: 2001,
pagine: 1105 - 1112
SICI:
0003-4975(200104)71:4<1105:PCFLCD>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPARING PERIOPERATIVE CHEMOTHERAPY; RESPIRATORY-DISTRESS SYNDROME; RANDOMIZED TRIAL; PHASE-II; CONSENSUS CONFERENCE; RADIATION-THERAPY; SURGERY; CARCINOMA; OUTCOMES; SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Putnam, JB Univ Texas, MD Anderson Canc Ctr, Dept Thorac & Cardiovasc Surg, 1515 Holcombe Blvd,Box 109, Houston, TX 77030 USA Univ Texas 1515 Holcombe Blvd,Box 109 Houston TX USA 77030 USA
Citazione:
M.P. Siegenthaler et al., "Preoperative chemotherapy for lung cancer does not increase surgical morbidity", ANN THORAC, 71(4), 2001, pp. 1105-1112

Abstract

Background. Preoperative chemotherapy (CCS) for non-small cell lung cancer(NSCLC) has increased in an attempt to improve survival. Patients receiving CCS potentially may have an increase in postoperative morbidity and mortality compared with surgery alone (S). We reviewed our experience with C+S and S in a tertiary referral center. Methods. Three hundred eighty consecutive patients underwent lobectomy or greater resection for NSCLC between August 1, 1996, and April 30, 1999: 335patients (259 S; 76 C+S) were analyzed; 45 additional patients were excluded for prior NSCLC, other chemotherapy for other malignancy, or radiation. We compared morbidity and mortality overall, and by subset analysis (clinical stage, pathological stage, procedure, and by protocol use) for both CCS and S patients. Results. Demographics, comorbidities, and spirometry were similar. We noted no significant difference in overall or subset mortality or morbidity including pneumonia, acute respiratory distress syndrome, reintubation, tracheostomy, wound complications, or length of hospitalization. Conclusions. C+S did not significantly affect morbidity or mortality overall, based on clinical stage, postoperative stage, or extent of resection. The potential for enhanced survival in resectable NSCLC justifies continued study of C+S. (C) 2001 by The Society of Thoracic Surgeons.

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Documento generato il 25/09/20 alle ore 00:15:36