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Titolo:
Mucosal immunity and viral infections
Autore:
Freihorst, J; Ogra, PL;
Indirizzi:
Med Hsch Hannover, Div Pediat Pulmonol & Neonatol, D-30625 Hannover, Germany Med Hsch Hannover Hannover Germany D-30625 ol, D-30625 Hannover, Germany Childrens Hosp, Div Infect Dis, Buffalo, NY 14222 USA Childrens Hosp Buffalo NY USA 14222 Div Infect Dis, Buffalo, NY 14222 USA
Titolo Testata:
ANNALS OF MEDICINE
fascicolo: 3, volume: 33, anno: 2001,
pagine: 172 - 177
SICI:
0785-3890(200104)33:3<172:MIAVI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY SYNCYTIAL VIRUS; T-CELLS; ALVEOLAR MACROPHAGES; IGA; SYSTEM; ANTIBODIES; RESPONSES; GAMMA; MICE; IMMUNOGLOBULINS;
Keywords:
Immunoglobulin A; immune response; infection; mucosa-associated lymphoid tissue; mucosal; vaccination; virus;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Freihorst, J Med Hsch Hannover, Div Pediat Pulmonol & Neonatol, Carl Neuberg Str 1, D-30625 Hannover, Germany Med Hsch Hannover Carl Neuberg Str 1 Hannover Germany D-30625
Citazione:
J. Freihorst e P.L. Ogra, "Mucosal immunity and viral infections", ANN MED, 33(3), 2001, pp. 172-177

Abstract

The mucosal surfaces are the first portals of entry for most infectious agents. among which respiratory and intestinal viruses are of greatest epidemiological importance. To combat these infections, the immune system uses unspecific and specific mechanisms. Unspecific responses include the production of virus-induced cytokines, such as type 1 interferons and natural killer (NK) cell activity, while specific immune responses mainly depend on cytotoxic T cells. which are important especially in the early course of a viral infection, and on antibodies. At the mucosal sites, antiviral secretory IgA antibodies play a major role in clearing viral infections and preventingor modifying disease after re-exposure. Passive transfer of virus-specificantibodies has been used in experimental and clinical settings to prevent or treat viral mucosal infections. In the future. the development of new mucosal vaccines promises to have the strongest impact on the epidemiology ofviral infections.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 03:29:53