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Titolo:
Enhanced expression and release of C-type natriuretic peptide in freshwater eels
Autore:
Takei, Y; Inoue, K; Ando, K; Ihara, T; Katafuchi, T; Kashiwagi, M; Hirose, S;
Indirizzi:
Univ Tokyo, Ocean Res Inst, Dept Marine Biosci, Div Physiol,Nakano Ku, Tokyo 1648639, Japan Univ Tokyo Tokyo Japan 1648639 v Physiol,Nakano Ku, Tokyo 1648639, Japan Nippon Paint Co Ltd, Shinagawa Ku, Tokyo 1408675, Japan Nippon Paint Co Ltd Tokyo Japan 1408675 inagawa Ku, Tokyo 1408675, Japan Tokyo Inst Technol, Dept Biol Sci, Midori Ku, Yokohama, Kanagawa 2268501, Japan Tokyo Inst Technol Yokohama Kanagawa Japan 2268501 anagawa 2268501, Japan
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 6, volume: 280, anno: 2001,
pagine: R1727 - R1735
SICI:
0363-6119(200106)280:6<R1727:EEAROC>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA; SEQUENCE-ANALYSIS; RECEPTOR-B; ATRIAL; CLONING; SYSTEM; BRAIN; PLASMA; RAT; DOGFISH;
Keywords:
cDNA cloning of eel CNP; natriuretic peptide family; tissue distribution of CNP mRNA; radioimmunoassay of eel CNP; osmoregulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Takei, Y Univ Tokyo, Ocean Res Inst, Dept Marine Biosci, Div Physiol,Nakano Ku, 1-15-1 Minamidai, Tokyo 1648639, Japan Univ Tokyo 1-15-1 Minamidai Tokyo Japan 1648639 o 1648639, Japan
Citazione:
Y. Takei et al., "Enhanced expression and release of C-type natriuretic peptide in freshwater eels", AM J P-REG, 280(6), 2001, pp. R1727-R1735

Abstract

C-type natriuretic peptide (CNP) is recognized as a paracrine factor acting locally in the brain and periphery. To assess the role of CNP in teleost fish, a cDNA encoding a CNP precursor was initially cloned from the eel brain. CNP message subsequently detected by ribonuclease protection assay, using the cDNA as probe, was most abundant in the brain followed by liver, gut, gills, and heart. Expression was generally higher in freshwater (FW) thanin seawater (SW) eels, but not in the brain. Plasma CNP concentration measured by a newly developed homologous radioimmunoassay for eel CNP was higher in FW than in SW eels. The CNP concentration was also higher in the heartof FW eels but not in the brain. These results show that CNP is abundantlysynthesized in peripheral tissues of FW eels and secreted constitutively into the circulation. Therefore, CNP is a circulating hormone as well as a paracrine factor in eels. Together with our previous demonstration that CNP-specific receptor expression is enhanced in FW eels, it appears that CNP isa hormone important for FW adaptation. Because atrial NP (ANP) promotes SWadaptation in eels, CNP and ANP, despite high sequence identity, appear tohave opposite effects on environmental adaptation of the euryhaline fish.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 20:51:06