Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Mineralocorticoid treatment attenuates activation of oxytocinergic and vasopressinergic neurons by icv ANG II
Autore:
Roesch, DM; Blackburn-Munro, RE; Verbalis, JG;
Indirizzi:
Georgetown Univ, Dept Med, Div Endocrinol & Metab, Washington, DC 20007 USA Georgetown Univ Washington DC USA 20007 & Metab, Washington, DC 20007 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 6, volume: 280, anno: 2001,
pagine: R1853 - R1864
SICI:
0363-6119(200106)280:6<R1853:MTAAOO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-FOS EXPRESSION; RECEPTOR MESSENGER-RNA; CENTRAL-NERVOUS-SYSTEM; INDUCED SALT APPETITE; ANGIOTENSIN-II; SODIUM APPETITE; RAT-BRAIN; PARAVENTRICULAR NUCLEUS; INTRACEREBROVENTRICULAR INFUSION; NEUROHYPOPHYSEAL SECRETION;
Keywords:
deoxycorticosterone acetate; vasopressin; salt appetite; c-Fos;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Roesch, DM Georgetown Univ, Dept Med, Div Endocrinol & Metab, 350 Bldg D,4000 Reservoir Rd NW, Washington, DC 20007 USA Georgetown Univ 350 Bldg D,4000 Reservoir Rd NW Washington DC USA 20007
Citazione:
D.M. Roesch et al., "Mineralocorticoid treatment attenuates activation of oxytocinergic and vasopressinergic neurons by icv ANG II", AM J P-REG, 280(6), 2001, pp. R1853-R1864

Abstract

Central oxytocin (OT) neurons limit intracerebroventricular (icv) ANG II-induced NaCl intake. Because mineralocorticoids synergistically increase ANGII-induced NaCl intake, we hypothesized that mineralocorticoids may attenuate ANG II-induced activation of inhibitory OT neurons. To test this hypothesis, we determined the effect of deoxycorticosterone (DOCA; 2 mg/day) on icv ANG II-induced c-Fos immunoreactivity in OT and vasopressin (VP) neuronsin the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus and also on pituitary OT and VP secretion in male rats. DOCA significantly decreased the percentage of c-Fos-positive (%c-Fos+) OT neurons in the SON and PVN, both in the magnocellular and parvocellular subdivisions, and the %c-Fos+ VP neurons in the SON after a 5-ng icv injection of ANG II. DOCAalso significantly reduced the %c-Fos+ OT neurons in the SON after 10 ng ANG II and tended to attenuate 10 ng ANG II-induced OT secretion. However, the %c-Fos+ OT neurons in DOCA-treated rats was greater after 10 ng ANG II, and DOCA did not affect the %c-Fos+ OT neurons in the PVN nor VP secretion or c-Fos immunoreactivity in either the SON or PVN after 10 ng ANG II. DOCAalso did not significantly alter the effect of intraperitoneal (ip) cholecystokinin (62 mug) on %c-Fos+ OT neurons or of ip NaCl (2 ml of 2 M NaCl) on the %c-Fos+ OT and VP neurons. These findings indicate that DOCA attenuates the responsiveness of OT and VP neurons to ANG II without completely suppressing the activity of these neurons and, therefore, support the hypothesis that attenuation of OT neuronal activity is one mechanism by which mineralocorticoids enhance NaCl intake.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 17:21:41