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Titolo:
Pregnancy alters cortisol feedback inhibition of stimulated ACTH: studies in adrenalectomized ewes
Autore:
Keller-Wood, M; Wood, CE;
Indirizzi:
Univ Florida, Coll Pharm, Dept Pharmacodynam, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610 acodynam, Gainesville, FL 32610 USA Univ Florida, Dept Physiol, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610 Physiol, Gainesville, FL 32610 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 6, volume: 280, anno: 2001,
pagine: R1790 - R1798
SICI:
0363-6119(200106)280:6<R1790:PACFIO>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
II CORTICOSTEROID RECEPTORS; GLUCOCORTICOID RECEPTOR; VASOPRESSIN RESPONSES; ADDISONIAN CRISIS; BLOOD-VOLUME; FETAL LAMBS; SHEEP; HEMORRHAGE; PITUITARY; OCCUPATION;
Keywords:
corticotropin; glucocorticoid; mineralocorticoid; feedback; arginine vasopressin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Keller-Wood, M Univ Florida, Coll Pharm, Dept Pharmacodynam, Box 100487, Gainesville, FL 32610 USA Univ Florida Box 100487 Gainesville FL USA 32610 32610 USA
Citazione:
M. Keller-Wood e C.E. Wood, "Pregnancy alters cortisol feedback inhibition of stimulated ACTH: studies in adrenalectomized ewes", AM J P-REG, 280(6), 2001, pp. R1790-R1798

Abstract

These studies test the hypothesis that pregnancy alters the feedback effects of cortisol on stimulated ACTH secretion. Ewes were sham-operated (Sham), or adrenalectomized (ADX) at similar to 108 days gestation and replaced with aldosterone (3 mug. kg(-1).day(-1)) and with cortisol at either of two doses (ADX + 0.6 and ADX + 1 mg.kg(-1).day(-1)); ewes were studied during pregnancy and postpartum. Mean cortisol levels produced in ADX ewes were similar to normal pregnant ewes (ADX+1) or nonpregnant ewes (ADX+0.6), respectively. Plasma ACTH concentrations in response to infusion of nitroprusside were significantly increased in the pregnant ADX+0.6 ewes (1,159 +/- 258 pg/ml) relative to pregnant Sham ewes (461 +/- 117 pg/ml) or the ADX+1 ewes (442 +/- 215 pg/ml) or the same ewes postpartum (151 +/- 69 pg/ml). Plasma ACTH concentrations were not significantly different among the groups postpartum. Increasing plasma cortisol to 20-30 ng/ml for 24 h before hypotensionproduced similar inhibition of ACTH in all groups. Pregnancy appears to decrease the effectiveness of low concentrations of cortisol to inhibit ACTH responses to hypotension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/12/18 alle ore 22:58:56