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Titolo:
Altered expression of C/EBP family members results in decreased adipogenesis with aging
Autore:
Karagiannides, I; Tchkonia, T; Dobson, DE; Steppan, CM; Cummins, P; Chan, G; Salvatori, K; Hadzopoulou-Cladaras, M; Kirkland, JL;
Indirizzi:
Boston Univ, Dept Med, Boston, MA 02118 USA Boston Univ Boston MA USA 02118 ston Univ, Dept Med, Boston, MA 02118 USA Boston Univ, Dept Pathol, Boston, MA 02118 USA Boston Univ Boston MA USA 02118 n Univ, Dept Pathol, Boston, MA 02118 USA Boston Univ, Dept Biochem, Boston, MA 02118 USA Boston Univ Boston MA USA02118 Univ, Dept Biochem, Boston, MA 02118 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 6, volume: 280, anno: 2001,
pagine: R1772 - R1780
SICI:
0363-6119(200106)280:6<R1772:AEOCFM>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING-PROTEIN-ALPHA; FED AD-LIBITUM; ADIPOSE-TISSUE; PPAR-GAMMA; GENE-EXPRESSION; 3T3-L1 PREADIPOCYTES; MESSENGER-RNA; ANATOMIC SITE; PEROXISOME PROLIFERATOR; ADIPOCYTE PRECURSORS;
Keywords:
preadipocytes; differentiation; C/EBP alpha; C/EBP beta; c/EBP delta;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Kirkland, JL Boston Univ, Dept Med, 88 E Newton St,F435, Boston, MA 02118 USA Boston Univ 88 E Newton St,F435 Boston MA USA 02118 02118 USA
Citazione:
I. Karagiannides et al., "Altered expression of C/EBP family members results in decreased adipogenesis with aging", AM J P-REG, 280(6), 2001, pp. R1772-R1780

Abstract

Fat mass, adipocyte size and metabolic responsiveness, and preadipocyte differentiation decrease between middle and old age. We show that expression of CCAAT/enhancer binding protein (C/EBP)-alpha, a key regulator of adipogenesis and fat cell function, declined substantially with aging in differentiating preadipocytes cultured under identical conditions from rats of various ages. Overexpression of C/EBP alpha in preadipocytes cultured from old rats restored capacity to differentiate into fat cells, indicating that downstream differentiation-dependent genes maintain responsiveness to regulators of adipogenesis. C/EBP alpha -expression also decreased with age in fat tissue from three different depots and in isolated fat cells. The overall level of C/EBP beta, which modulates C/EBP alpha -expression, did not change with age, but the truncated, dominant-negative C/EBP beta -liver inhibitoryprotein (LIP) isoform increased in cultured preadipocytes and isolated fatcells. Overexpression of C/EBP beta -LIP in preadipocytes from young rats impaired adipogenesis. C/EBP delta, which acts with full-length C/EBP beta to enhance adipogenesis, decreased with age. Thus processes intrinsic to adipose cells involving changes in C/EBP family members contribute to impaired adipogenesis and altered fat tissue function with aging. These effects are potentially reversible.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:46:09