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Titolo:
Hypothesis testing of the aging male gonadal axis via a biomathematical construct
Autore:
Keenan, DM; Veldhuis, JD;
Indirizzi:
Univ Virginia, Ctr Biomath Technol, Charlottesville, VA 22908 USA Univ Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA Univ Virginia, Dept Stat, Charlottesville, VA 22908 USA Univ Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA Gen Clin Res Ctr, Hlth Sci Ctr, Dept Internal Med, Div Endocrinol, Charlottesville, VA 22908 USA Gen Clin Res Ctr Charlottesville VA USA 22908 arlottesville, VA 22908 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 6, volume: 280, anno: 2001,
pagine: R1755 - R1771
SICI:
0363-6119(200106)280:6<R1755:HTOTAM>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOLLICLE-STIMULATING-HORMONE; LUTEINIZING-HORMONE; AGED MEN; GROWTH-HORMONE; ELDERLY MEN; BIOAVAILABLE TESTOSTERONE; APPROXIMATE ENTROPY; OLDER MEN; LH; PULSATILE;
Keywords:
gonadotropin-releasing hormone; luteinizing hormone; Leydig cell testosterone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Veldhuis, JD Univ Virginia, Ctr Biomath Technol, POB 800202, Charlottesville, VA 22908 USA Univ Virginia POB 800202 Charlottesville VA USA 22908 908 USA
Citazione:
D.M. Keenan e J.D. Veldhuis, "Hypothesis testing of the aging male gonadal axis via a biomathematical construct", AM J P-REG, 280(6), 2001, pp. R1755-R1771

Abstract

Neuroendocrine axes are feedback- and feedforward-coupled dynamic ensembles. Disruption of selected pathways in such networklike organizations may explicate loss of orderly hormonal output as observed in aging. To test this notion more explicitly, we implemented an earlier computer-assisted biomathematical model of the interlinked male hypothalamo [gonadotropin-releasing hormone (GnRH)]-pituitary [luteinizing hormone, (LH)]-testicular [Leydig cell testosterone (Te)] axis (Am J Physiol Endocrinol Metab Physiol 275: E157-E176, 1988; Keenan D., W. Sun, and J. D. Veldhuis, SIAM J Appl Math 61: 934-965, 2000). Thereby, we appraise mechanistic hypotheses for more disorderly LH and Te secretion in aging men. We compare model predictions with monitored abnormalities in the older male, namely, irregular patterns of individual and synchronous LH and Te release, reduced 24-h rhythmic Te output, and variably elevated LH secretion. Among the mechanisms examined, the most parsimonious aging hypothesis would entail impaired LH feedforward on Te without or with attenuated Te feedback on GnRH/LH secretion. This investigative strategy should aid in exploring new postulates of disrupted feedback networks in pathophysiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 08:49:00