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Titolo:
Neuronal histamine release elicited by hyperthermia mediates tracheal dilation and pressor response
Autore:
Kanamaru, M; Iwase, M; Homma, I;
Indirizzi:
Showa Univ, Sch Med, Dept Physiol, Shinagawa Ku, Tokyo 1428555, Japan Showa Univ Tokyo Japan 1428555 ysiol, Shinagawa Ku, Tokyo 1428555, Japan
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 6, volume: 280, anno: 2001,
pagine: R1748 - R1754
SICI:
0363-6119(200106)280:6<R1748:NHREBH>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ROSTRAL VENTROLATERAL MEDULLA; TEMPERATURE-INDUCED POLYPNEA; RAT; RABBIT; TENSION; BRAIN; AREA; MICE;
Keywords:
H-1 receptors; microdialysis; trachea; body temperature; rostral ventrolateral medulla;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Homma, I Showa Univ, Sch Med, Dept Physiol, Shinagawa Ku, 1-5-8 Hatanodai,Tokyo 1428555, Japan Showa Univ 1-5-8 Hatanodai Tokyo Japan 1428555 yo 1428555, Japan
Citazione:
M. Kanamaru et al., "Neuronal histamine release elicited by hyperthermia mediates tracheal dilation and pressor response", AM J P-REG, 280(6), 2001, pp. R1748-R1754

Abstract

Whether brain histaminergic neurons contribute to the regulation of tracheal tone and peripheral vascular tone under hyperthermia was investigated inanesthetized rabbits. Histamine release from the rostral ventrolateral medulla (RVLM), the raphe nuclei, and the solitary nucleus of the medulla oblongata was significantly increased by hyperthermia. The increased histamine was significantly suppressed by 10(-6) M tetrodotoxin microdialyzed in eacharea. Tracheal pressure and mean arterial pressure were significantly decreased and increased by hyperthermia, respectively. An H-1-receptor antagonist, 5 x 10(-6) M (+)- chlorpheniramine, bilaterally microdialyzed in the RVLM significantly enhanced histamine release in the RVLM as well as significantly suppressed tracheal dilation and pressor response caused by hyperthermia. These data indicate that histamine release in the medulla oblongata isenhanced by hyperthermia. The enhanced histamine is the neuronal origin and the cause of tracheal dilation and pressor response at least via H-1 receptors in the RVLM. Brain histaminergic neurons play important roles in tracheal tone and peripheral vascular tone via H-1 receptors in the RVLM and homeostasis on body temperature.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 01:55:34