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Titolo:
Inherent capacity for lipogenesis or dietary fat retention is not increased in obesity-prone rats
Autore:
Commerford, SR; Pagliassotti, MJ; Melby, CL; Wei, YR; Hill, JO;
Indirizzi:
Univ Colorado, Hlth Sci Ctr, Dept Pediat, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 Ctr, Dept Pediat, Denver, CO 80262 USA Colorado State Univ, Dept Food Sci & Human Nutr, Ft Collins, CO 80525 USA Colorado State Univ Ft Collins CO USA 80525 utr, Ft Collins, CO 80525 USA Arizona State Univ, Exercise Sci Res Inst, Tempe, AZ 85287 USA Arizona State Univ Tempe AZ USA 85287 e Sci Res Inst, Tempe, AZ 85287 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 6, volume: 280, anno: 2001,
pagine: R1680 - R1687
SICI:
0363-6119(200106)280:6<R1680:ICFLOD>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATOCYTES;
Keywords:
tritium; liver; adipose tissue; energy intake; high-fat diet;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Commerford, SR Univ Pittsburgh, Med Ctr, Dept Med Endocrinol, E1112 BiomedSci Tower,Lothrop St, Pittsburgh, PA 15261 USA Univ Pittsburgh E1112 Biomed Sci Tower,Lothrop St Pittsburgh PA USA 15261
Citazione:
S.R. Commerford et al., "Inherent capacity for lipogenesis or dietary fat retention is not increased in obesity-prone rats", AM J P-REG, 280(6), 2001, pp. R1680-R1687

Abstract

Obesity results from positive energy balance and, perhaps, abnormalities in lipid and glycogen metabolism. The purpose of this study was to determinewhether differences in lipogenesis, retention of dietary fat, and/or glycogenesis influenced susceptibility to dietary obesity. After 1 wk of free access to a high-fat diet (HFD; 45% fat by energy) rats were separated on thebasis of 1 wk body weight gain into obesity-prone (OP; greater than or equal to 48 g) or obesity-resistant groups (OR; less than or equal to 40 g). Rats were either studied at this time (OR1, OP1) or continued on the HFD foran additional 4 wk (OR5, OP5). Weight gain and energy intake were greater (P less than or equal to 0.05) in OP vs. OR at both 1 (53 +/- 2 vs. 34 +/- 1 g; 892 +/- 27 vs. 755 +/- 14 kcal) and 5 (208 +/- 7 vs. 170 +/- 7 g; 4,484 +/- 82 vs. 4,008 +/- 72 kcal) wk, respectively. Rats were injected with (H2O)-H-3 and were either provided free access to an HFD meal containing labeled fatty acids (fed; n = 10 or 11/group) or were fasted (n = 10/group) overnight. The amount of food or C-14 tracer eaten overnight was equivalent between OP and OR rats. In liver, the fraction of H-3 retained in glycogen or lipid was not significantly different between OR and OP groups. Retentionof dietary fat in the liver was not increased in OP rats. In adipose tissue, retention of H-3 was similar to 49% greater (P less than or equal to 0.05) in OP1 vs. OR1 and similar to 30% greater in OP5 vs. OR5, but retention of dietary fat was not elevated in OP vs. OR. At the same time, fat pad weight (sum of epididymal, retroperitoneal, mesenteric) was 49% greater in OP1rats vs. OR1 rats and 65% greater in OP5 vs. OR5 rats (P less than or equal to 0.05). Thus a greater capacity for lipogenesis or retention of dietaryfat does not appear to be included in the OP phenotype. The characteristicincrease in energy intake associated with OP rats appears to be necessary and critical to accelerated weight and fat gain.

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Documento generato il 26/11/20 alle ore 11:46:25