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Titolo:
Endogenous angiotensin II in the NTS contributes to sympathetic activationin rats with aortocaval shunt
Autore:
Shigematsu, H; Hirooka, Y; Eshima, K; Shihara, M; Tagawa, T; Takeshita, A;
Indirizzi:
Kyushu Univ, Grad Sch Med Sci, Dept Cardiovasc Med, Higashi Ku, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 ed, Higashi Ku, Fukuoka 8128582, Japan
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 6, volume: 280, anno: 2001,
pagine: R1665 - R1673
SICI:
0363-6119(200106)280:6<R1665:EAIITN>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-TRACTUS-SOLITARIUS; EXPERIMENTAL HEART-FAILURE; ROSTRAL VENTROLATERAL MEDULLA; NITRIC-OXIDE SYNTHASE; NERVE ACTIVITY; CONVERTING ENZYME; BRAIN-STEM; MYOCARDIAL-INFARCTION; GENE-EXPRESSION; MESSENGER-RNA;
Keywords:
arteriovenous fistula; brain; sympathetic nervous system; heart failure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Hirooka, Y Kyushu Univ, Grad Sch Med Sci, Dept Cardiovasc Med, Higashi Ku,3-1-1 Maidashi, Fukuoka 8128582, Japan Kyushu Univ 3-1-1 Maidashi FukuokaJapan 8128582 128582, Japan
Citazione:
H. Shigematsu et al., "Endogenous angiotensin II in the NTS contributes to sympathetic activationin rats with aortocaval shunt", AM J P-REG, 280(6), 2001, pp. R1665-R1673

Abstract

Recent studies have suggested that the central nervous system is responsible for activation of sympathetic nerve activity (SNA) and the renin-angiotensin system in heart failure (HF). The aim of this study was to determine whether activation of the renin-angiotensin system within the nucleus of thesolitary tract (NTS) plays a role in enhanced SNA in HF. High-output HF was induced by an aortocaval (A-V) shunt with some modifications in the rat. These rats exhibited a left ventricular dilatation and hemodynamic signs ofhigh-output HF. Urinary catecholamine excretion and maximal renal SNA (RSNA) were greater in the A-V shunted rats than in the control rats. Microinjection of an angiotensin II type 1-receptor antagonist, CV11974, into the NTS was performed. The arterial pressure and RSNA were reduced by CV11974 to a greater degree in the A-V shunted rats than in the control rats. The expression of angiotensin-converting enzyme mRNA in the medulla was greater in the A-V shunted rats than in the control rats. These results suggest that activation of the renin-angiotensin system within the NTS contributes to an enhanced SNA in this model.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:23:17