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Titolo:
Muscarinic modulation of GABAergic transmission to neurons in the rat subfornical organ
Autore:
Xu, SH; Honda, E; Ono, K; Inenaga, K;
Indirizzi:
Kyushu Dent Coll, Dept Physiol, Kokurakita Ku, Kitakyushu, Fukuoka 8038580, Japan Kyushu Dent Coll Kitakyushu Fukuoka Japan 8038580 Fukuoka 8038580, Japan
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 6, volume: 280, anno: 2001,
pagine: R1657 - R1664
SICI:
0363-6119(200106)280:6<R1657:MMOGTT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCITATORY SYNAPTIC INPUTS; GAMMA-AMINOBUTYRIC-ACID; ANGIOTENSIN-II; INHIBITORY INPUTS; PRESSOR-RESPONSES; SLICE PREPARATION; RECEPTOR; NUCLEUS; DRINKING; BRAIN;
Keywords:
inhibitory postsynaptic current; synaptic input; acetylcholine; patch clamp;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Inenaga, K Kyushu Dent Coll, Dept Physiol, Kokurakita Ku, Kitakyushu, Fukuoka 8038580, Japan Kyushu Dent Coll Kitakyushu Fukuoka Japan 8038580 38580, Japan
Citazione:
S.H. Xu et al., "Muscarinic modulation of GABAergic transmission to neurons in the rat subfornical organ", AM J P-REG, 280(6), 2001, pp. R1657-R1664

Abstract

Cholinergic actions on subfornical organ (SFO) neurons in rat slice preparations were studied by using whole cell voltage- and current-clamp recordings. In the voltage- clamp recordings, carbachol and muscarine decreased thefrequency of GABAergic inhibitory postsynaptic currents (IPSCs) in a dose-dependent manner, with no effect on the amplitudes or the time constants ofminiature IPSCs. Meanwhile, carbachol did not influence the amplitude of the outward currents induced by GABA. Furthermore, carbachol and muscarine also elicited inward currents in a TTX-containing solution. From the current-voltage relationship, the reversal potential was estimated to be -7.1 mV. These carbachol-induced responses were antagonized by atropine. In the current-clamp recordings, carbachol depolarized the membrane with increased frequency of action potentials. These observations suggest that acetylcholine suppresses GABA release through muscarinic receptors located on the presynaptic terminals. Acetylcholine also directly affects the postsynaptic membrane through muscarinic receptors, by opening nonselective cation channels. Acombination of these presynaptic and postsynaptic actions may enhance activation of SFO neurons by acetylcholine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:28:58