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Titolo:
Effect of carotid or aortic baroreceptor denervation on arterial pressure during hemorrhage in conscious dogs
Autore:
Thrasher, TN; Shifflett, C;
Indirizzi:
Univ Maryland, Sch Med, Dept Surg, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 , Dept Surg, Baltimore, MD 21201 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 6, volume: 280, anno: 2001,
pagine: R1642 - R1649
SICI:
0363-6119(200106)280:6<R1642:EOCOAB>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL NERVE ACTIVITY; RABBITS; AFFERENTS; RECEPTORS; REFLEX;
Keywords:
blood pressure; hypovolemia; blood volume; ventricular receptors; arterial baroreceptors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Thrasher, TN Univ Maryland, Sch Med, Dept Surg, 10 S Pine St,Rm 400, Baltimore, MD 21201 USA Univ Maryland 10 S Pine St,Rm 400 Baltimore MD USA 21201 USA
Citazione:
T.N. Thrasher e C. Shifflett, "Effect of carotid or aortic baroreceptor denervation on arterial pressure during hemorrhage in conscious dogs", AM J P-REG, 280(6), 2001, pp. R1642-R1649

Abstract

We studied the effect of chronically denervating aortic baroreceptors (ABR; n = 6) or carotid baroreceptors (CBR; n = 7) on mean arterial pressure (MAP) and heart rate (HR) responses to hemorrhage in the dog. Neither denervation had a significant effect on basal MAP, the variability (standard deviation) of MAP, or resting HR. However, the breakpoint of MAP (defined as thevolume of blood removed when MAP fell more than 10% below control and declined monotonically thereafter) was significantly reduced in dogs with only ABR functional (12.4 +/- 1.4 ml/kg) compared with the volume in the intact condition (18.9 +/- 1.8 ml/kg). In contrast, there was no difference in thebreakpoint or the MAP at any time during hemorrhage in dogs with both CBR functional compared with their intact responses. In a different group of dogs (n = 6), responses were determined with both CBR operating and again after unilateral denervation, leaving only one CBR (1CBR) functional. Basal MAP and the variability of MAP were not altered in dogs with only 1CBR functional, but the breakpoint (11.7 +/- 1.4 ml/kg) during hemorrhage was significantly different compared with responses with two CBR (21.2 +/- 2.3 ml/kg),and MAP fell to much lower levels. These results indicate that the CBR cancompensate fully for loss of ABR during hemorrhage but not vice versa; andbilateral CBR inputs are required for normal responses to hemorrhage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 10:57:30