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Titolo:
Mast cells are involved in the gastric hyperemic response to acid back diffusion via release of histamine
Autore:
Rydning, A; Lyng, O; Adamsen, BL; Falkmer, S; Sandvik, AK; Gronbech, JE;
Indirizzi:
Norwegian Univ Sci & Technol, Dept Surg, N-7006 Trondheim, Norway Norwegian Univ Sci & Technol Trondheim Norway N-7006 6 Trondheim, Norway Norwegian Univ Sci & Technol, Dept Lab Med, N-7006 Trondheim, Norway Norwegian Univ Sci & Technol Trondheim Norway N-7006 6 Trondheim, Norway Norwegian Univ Sci & Technol, Dept Physiol, N-7006 Trondheim, Norway Norwegian Univ Sci & Technol Trondheim Norway N-7006 6 Trondheim, Norway
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
fascicolo: 6, volume: 280, anno: 2001,
pagine: G1061 - G1069
SICI:
0193-1857(200106)280:6<G1061:MCAIIT>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFUSED RAT STOMACH; GENE-RELATED PEPTIDE; SUBSTANCE-P; BLOOD-FLOW; SENSORY NEURONS; HYPERTONIC SALINE; MUCOSAL HYPEREMIA; CAT; DAMAGE; VASODILATATION;
Keywords:
sensory neurons; thioperamide; pyrilamine; enterochromaffin-like cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Rydning, A Univ Trondheim Hosp, Dept Surg, N-7006 Trondheim, Norway Univ Trondheim Hosp Trondheim Norway N-7006 Trondheim, Norway
Citazione:
A. Rydning et al., "Mast cells are involved in the gastric hyperemic response to acid back diffusion via release of histamine", AM J P-GAST, 280(6), 2001, pp. G1061-G1069

Abstract

Acid back diffusion into the rat stomach mucosa leads to gastric vasodilation. We hypothesized that histamine, if released from the rat mucosa under such conditions, is mast cell derived and involved in the vasodilator response. Gastric blood flow (GBF) and luminal histamine were measured in an ex vivo chamber. Venous histamine was measured from totally isolated stomachs. Mucosal mast cells (MMC), submucosal connective tissue mast cells (CTMC), and chromogranin A-immunoreactive cells (CgA IR) were assessed morphometrically. After mucosal exposure to 1.5 M NaCl, the mucosa was subjected to saline at pH 5.5 (control) or pH 1.0 (H+ back diffusion) for 60 min. H+ back diffusion evoked a marked gastric hyperemia, increase of luminal and venous histamine, and decreased numbers of MMC and CTMC. CgA IR cells were not influenced. Depletion of mast cells with dexamethasone abolished (and stabilization of mast cells with ketotifen attenuated) both hyperemia and histaminerelease in response to H+ back diffusion. GBF responses to H+ back diffusion were attenuated by H-1 and abolished by H-3 but not H-2 receptor blockers. Our data conform to the idea that mast cells are involved in the gastrichyperemic response to acid back diffusion via release of histamine.

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Documento generato il 02/12/20 alle ore 15:30:13