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Titolo:
Mechanisms in regulating the release of serotonin from the perfused rat stomach
Autore:
Yu, PL; Fujimura, M; Hayashi, N; Nakamura, T; Fujimiya, M;
Indirizzi:
Shiga Univ Med Sci, Dept Anat, Shiga 5202192, Japan Shiga Univ Med Sci Shiga Japan 5202192 , Dept Anat, Shiga 5202192, Japan Shiga Univ Med Sci, Dept Surg 2, Shiga 5202192, Japan Shiga Univ Med Sci Shiga Japan 5202192 Dept Surg 2, Shiga 5202192, Japan
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
fascicolo: 6, volume: 280, anno: 2001,
pagine: G1099 - G1105
SICI:
0193-1857(200106)280:6<G1099:MIRTRO>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE INTESTINAL POLYPEPTIDE; GASTRIC-ACID SECRETION; PIG SMALL-INTESTINE; GUINEA-PIG; GASTROINTESTINAL-TRACT; ENTEROCHROMAFFIN CELLS; LUMINAL RELEASE; MOTOR-ACTIVITY; NITRIC-OXIDE; 5-HYDROXYTRYPTAMINE;
Keywords:
isolated perfusion; enterochromaffin cells; somatostatin; peptide YY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Fujimiya, M Shiga Univ Med Sci, Dept Anat, Shiga 5202192, Japan Shiga UnivMed Sci Shiga Japan 5202192 Shiga 5202192, Japan
Citazione:
P.L. Yu et al., "Mechanisms in regulating the release of serotonin from the perfused rat stomach", AM J P-GAST, 280(6), 2001, pp. G1099-G1105

Abstract

The mechanisms regulating the release of serotonin into the portal circulation as well as into the gastric lumen were studied in the isolated vascularly and luminally perfused rat stomach. Immunohistochemical study of the rat stomach showed that serotonin-containing enterochromaffin (EC) cells weredensely packed in the antral mucosa, sparsely scattered in the corpus, andnot found in the fundus. Such morphological findings suggest that serotonin detected in this study may have originated from antral EC cells. Luminal acidification stimulated the vascular release of serotonin but did not affect the luminal release of serotonin. The basal release of serotonin into the vasculature was 10 times higher than that into the gastric lumen at intragastric pH 2. The vascular release of serotonin is regulated by stimulationfrom cholinergic nicotinic mechanisms, whereas inhibitory neurotransmitters such as vasoactive intestinal peptide and NO are probably not involved. Somatostatin and peptide YY originating from endocrine cells may exert direct inhibitory effects, possibly via somatostatin and peptide YY receptors onthe EC cells, and a cholinergic muscarinic mechanism may exert indirect effects on the vascular release of serotonin via the muscarinic receptor on the endocrine cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:40:14