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Titolo:
Signaling mechanisms mediating vascular protective actions of vascular endothelial growth factor
Autore:
Zachary, I;
Indirizzi:
Univ London Univ Coll, Dept Med, London WC1E 6JJ, England Univ London UnivColl London England WC1E 6JJ , London WC1E 6JJ, England
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
fascicolo: 6, volume: 280, anno: 2001,
pagine: C1375 - C1386
SICI:
0363-6143(200106)280:6<C1375:SMMVPA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; FOCAL ADHESION KINASE; SMOOTH-MUSCLE CELLS; RECEPTOR TYROSINE KINASES; BLOOD-VESSEL DEVELOPMENT; PERMEABILITY FACTOR; PROTEIN-KINASE; VEGF RECEPTOR-1; TISSUE FACTOR; GENE-TRANSFER;
Keywords:
angiogenesis; prostacyclin; nitric oxide; kinase domain receptor; apoptosis; endothelium;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
131
Recensione:
Indirizzi per estratti:
Indirizzo: Zachary, I Univ London Univ Coll, Dept Med, 5 Univ St, London WC1E 6JJ, England Univ London Univ Coll 5 Univ St London England WC1E 6JJ ngland
Citazione:
I. Zachary, "Signaling mechanisms mediating vascular protective actions of vascular endothelial growth factor", AM J P-CELL, 280(6), 2001, pp. C1375-C1386

Abstract

Vascular endothelial growth factor (VEGF) is essential for angiogenesis inhealth and pathophysiology, and it is currently a major focus for drug targeting in the development of treatments for diverse human diseases. Recently, we proposed that VEGF could also play a role as a vascular protective factor in the adult vasculature and in disease. In this model, vascular protection is defined as a VEGF-induced enhancement of endothelial functions that mediate the inhibition of vascular smooth muscle cell proliferation, enhanced endothelial cell survival, suppression of thrombosis, and anti-inflammatory effects. A feature of this model is that protective effects of VEGF are essentially independent of angiogenesis or endothelial cell proliferation. VEGF-dependent cell survival and VEGF-induced synthesis of nitric oxide and prostacyclin are likely to be key mediators of a vascular protective effect. Vascular protection should help to improve insight into the underlying mechanisms of cardiovascular actions of VEGF and prove valuable for developing novel therapeutic approaches to cardiovascular disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 03:46:09