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Titolo:
Simultaneous measurement of regional cerebral blood flow by perfusion CT and stable xenon CT: A validation study
Autore:
Wintermark, M; Thiran, JP; Maeder, P; Schnyder, P; Meuli, R;
Indirizzi:
CHU Vaudois, Univ Hosp, Dept Diagnost & Intervent Radiol, CH-1011 Lausanne, Switzerland CHU Vaudois Lausanne Switzerland CH-1011 , CH-1011 Lausanne, Switzerland Swiss Fed Inst Technol, Signal Proc Lab, CH-1015 Lausanne, Switzerland Swiss Fed Inst Technol Lausanne Switzerland CH-1015 ausanne, Switzerland
Titolo Testata:
AMERICAN JOURNAL OF NEURORADIOLOGY
fascicolo: 5, volume: 22, anno: 2001,
pagine: 905 - 914
SICI:
0195-6108(200105)22:5<905:SMORCB>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTRAST-MEDIUM INJECTION; COMPUTED-TOMOGRAPHY; ISCHEMIC STROKE; BOLUS GEOMETRY; TRANSIT-TIME; ENHANCED CT; VOLUME; BRAIN; THRESHOLDS; PENUMBRA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Meuli, R CHU Vaudois, Univ Hosp, Dept Diagnost & Intervent Radiol, BH10, CH-1011 Lausanne, Switzerland CHU Vaudois BH10 Lausanne Switzerland CH-1011sanne, Switzerland
Citazione:
M. Wintermark et al., "Simultaneous measurement of regional cerebral blood flow by perfusion CT and stable xenon CT: A validation study", AM J NEUROR, 22(5), 2001, pp. 905-914

Abstract

BACKGROUND AND PURPOSE: Knowledge of cerebral blood how (CBF) alterations in cases of acute stroke could be valuable in the early management of thesecases. Among imaging techniques affording evaluation of cerebral perfusion, perfusion CT studies involve sequential acquisition of cerebral CT sections obtained in an axial mode during the IV administration of iodinated contrast material. They are thus very easy to perform in emergency settings, Perfusion CT values of CBF hare proved to be accurate in animals, and perfusion CT affords plausible values in humans, The purpose of this study was to validate perfusion CT studies of CBF by comparison with the results provided by stable xenon CT, which have been reported to be accurate, and to evaluate acquisition and processing modalities of CT data, notably the possible deconvolution methods and the selection of the reference artery. METHODS: Twelve stable xenon CT and perfusion CT cerebral examinations were performed within an interval of a few minutes in patients with various cerebrovascular diseases, CBF maps were obtained from perfusion CT data by deconvolution using singular value decomposition and least mean square methods. The CBF were compared with the stable xenon CT results in multiple regions of interest through linear regression analysis and bilateral t tests formatched variables. RESULTS: Linear regression analysis showed good correlation between perfusion CT and stable xenon CT CBF values (singular value decomposition method:R-2 = 0.79, slope = 0.87; least mean square method: R-2 = 0.67, slope = 0.83). Bilateral t tests for matched variables did not identify a significantdifference between the two imaging methods (P > .1), Both deconvolution methods were equivalent (P > .1). The choice of the reference artery is a major concern and has a strong influence on the final perfusion CT CBF map. CONCLUSION: Perfusion CT studies of CBF achieved with adequate acquisitionparameters and processing lead to accurate and reliable results.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:26:09