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Titolo:
Extreme warfarin sensitivity in siblings associated with multiple cytochrome P450 polymorphisms
Autore:
Tabrizi, AR; McGrath, SD; Blinder, MA; Buchman, TG; Zehnbauer, BA; Freeman, BD;
Indirizzi:
Washington Univ, Sch Med, Dept Surg, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 , Dept Surg, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Dept Pediat, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 d, Dept Med, St Louis, MO 63110 USA
Titolo Testata:
AMERICAN JOURNAL OF HEMATOLOGY
fascicolo: 2, volume: 67, anno: 2001,
pagine: 144 - 146
SICI:
0361-8609(200106)67:2<144:EWSISA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALLELIC VARIANT; METABOLISM; COUMARIN; CYP2C9;
Keywords:
warfarin; cytochrome P450 complex; siblings;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Freeman, BD Washington Univ, Sch Med, Dept Surg, Box 8109, St Louis, MO 63110 USA Washington Univ Box 8109 St Louis MO USA 63110 s, MO 63110 USA
Citazione:
A.R. Tabrizi et al., "Extreme warfarin sensitivity in siblings associated with multiple cytochrome P450 polymorphisms", AM J HEMAT, 67(2), 2001, pp. 144-146

Abstract

Warfarin use is complicated by an erratic dose response. Warfarin is metabolized by two distinct subfamilies of the cytochrome P450 (CYP) complex. Wedescribe two siblings with extreme sensitivity to warfarin who share an unusual CYP genotype, These individuals illustrate both the importance of genetics in influencing the metabolism of warfarin as well as the potential utility of genetic testing as a guide to prescribing this medication. Am. J. Hematol, 67:144-146, 2001, (C) 2001 Wiley-Liss. Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 09:44:18