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Titolo:
Evaluation of two putative susceptibility loci for oral clefts in the Danish population
Autore:
Mitchell, LE; Murray, JC; OBrien, S; Christensen, K;
Indirizzi:
Univ So Denmark, Inst Publ Hlth, Ctr Prevent Congenital Malformat, DK-5000Odense C, Denmark Univ So Denmark Odense Denmark C tal Malformat, DK-5000Odense C, Denmark Univ Penn, Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Epidemiol, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Dept Pediat, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 pt Pediat, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 & Biostat, Philadelphia, PA 19104 USA Univ Iowa, Dept Pediat, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 wa, Dept Pediat, Iowa City, IA 52242 USA
Titolo Testata:
AMERICAN JOURNAL OF EPIDEMIOLOGY
fascicolo: 10, volume: 153, anno: 2001,
pagine: 1007 - 1015
SICI:
0002-9262(20010515)153:10<1007:EOTPSL>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-GENE VARIANTS; OROFACIAL CLEFTS; CANDIDATE GENES; BIRTH-DEFECTS; ALCOHOL-CONSUMPTION; CIGARETTE-SMOKING; TOOTH AGENESIS; PALATE; MSX1; LIP;
Keywords:
case-control studies; cleft lip; cleft palate; genetics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Mitchell, LE Univ So Denmark, Inst Publ Hlth, Ctr Prevent Congenital Malformat, Sdr Blvd 23A, DK-5000 Odense C, Denmark Univ So Denmark Sdr Blvd 23A Odense Denmark C nse C, Denmark
Citazione:
L.E. Mitchell et al., "Evaluation of two putative susceptibility loci for oral clefts in the Danish population", AM J EPIDEM, 153(10), 2001, pp. 1007-1015

Abstract

Previous studies suggest that the risk of nonsyndromic cleft lip with or without cleft palate (CL +/-P) and isolated cleft palate (CP) is influenced by genetic variation at several loci and that the relation between specificgenetic variants and disease risk may be modified by environmental factors. The present study evaluated potential associations between CL +/-P and CPand two putative clefting susceptibility loci, MSX1 and TGFB3, using data from a nationwide case-control study conducted in Denmark from 1991 to 1994. The potential effects of interactions between these genes and two common environmental exposures, first trimester exposure to maternal cigarette smoke and alcohol intake, were also examined, Analyses of these data provide evidence of an association between the risk of CP and variation at the TGFB3locus. However, there is no evidence that the risk of CL +/-P or CP is influenced by gene-environment interactions involving MSX1 or TGFB3 and eitherfirst trimester exposure to maternal cigarette smoke or alcohol consumption.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 01:32:10