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Titolo:
Low density lipoprotein particle size and risk of early-onset myocardial infarction in women
Autore:
Kamigaki, AS; Siscovick, DS; Schwartz, SM; Psaty, BM; Edwards, KL; Raghunathan, TE; Austin, MA;
Indirizzi:
Univ Washington, Sch Publ Hlth & Community Med, Dept Epidemiol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Epidemiol, Seattle, WA 98195 USA Univ Washington, Sch Med, Dept Med, Seattle, WA 98195 USA Univ WashingtonSeattle WA USA 98195 Med, Dept Med, Seattle, WA 98195 USA Univ Michigan, Inst Social Res, Survey Methodol Program, Ann Arbor, MI USAUniv Michigan Ann Arbor MI USA urvey Methodol Program, Ann Arbor, MI USA
Titolo Testata:
AMERICAN JOURNAL OF EPIDEMIOLOGY
fascicolo: 10, volume: 153, anno: 2001,
pagine: 939 - 945
SICI:
0002-9262(20010515)153:10<939:LDLPSA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; INSULIN-RESISTANCE SYNDROME; DOSE ORAL-CONTRACEPTIVES; FACTOR-V-LEIDEN; ARTERY DISEASE; YOUNG-WOMEN; PLASMA TRIGLYCERIDE; HDL CHOLESTEROL; LDL; MEN;
Keywords:
coronary disease; lipoproteins; HDL; lipoproteins; LDL; myocardial infarction; triglycerides;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Austin, MA Univ Washington, Sch Publ Hlth & Community Med, Dept Epidemiol,Box 357236,1959 NE Pacific Ave, Seattle, WA 98195 USA Univ Washington Box 357236,1959 NE Pacific Ave Seattle WA USA 98195
Citazione:
A.S. Kamigaki et al., "Low density lipoprotein particle size and risk of early-onset myocardial infarction in women", AM J EPIDEM, 153(10), 2001, pp. 939-945

Abstract

Previous studies of middle-aged men have shown a univariate association between low density lipoprotein (LDL) particle diameter (size) and coronary heart disease, but this association has yet to be examined in younger women. Using a subsample from a population-based case-control study of women living in western Washington State, the authors examined the association between LDL particle size and risk of early-onset myocardial infarction (MI) in 1992-1995. Gradient gel electrophoresis was used to characterize LDL subclasses in nonfasting blood samples from 72 MI cases and 159 controls aged 20-44 years. Mean LDL particle size in cases was significantly smaller comparedwith controls (26.4 vs. 26.9 nm, p < 0.001), with an odds ratio of 2.3 (p < 0.0001) for a 1-nm smaller LDL particle size. These results were independent of age, menopausal status, smoking, diabetes, hypertension, and LDL cholesterol (odds ratios = 1.9-2.3 for a l-nm smaller LDL particle size, all p< 0.02) but were not independent of body mass index, high density lipoprotein cholesterol, or triglyceride (odds ratios = 1.4, 1.4, and 1.1, respectively; all p > 0.05). Therefore, in age-adjusted analyses, smaller LDL particle size was associated with MI in young women, but the risk was attenuatedafter adjustments for metabolic factors related to both LDL particle size and MI.

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Documento generato il 03/12/20 alle ore 11:49:08