Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of central and systemic injections of peripheral benzodiazepine receptor ligands on the anxiolytic actions of ethanol in rats
Autore:
Morato, GS; Ferreira, VMM; Ferrara, P; Farges, RC;
Indirizzi:
Univ Fed Santa Catarina, Dept Farmacol, Ctr Ciencias Biol, BR-88015420 Florianopolis, SC, Brazil Univ Fed Santa Catarina Florianopolis SC Brazil BR-88015420 BC SC, Brazil Sanofi Synthelabo Rech Labege, F-31676 Labege, France Sanofi Synthelabo Rech Labege Labege France F-31676 31676 Labege, France
Titolo Testata:
ADDICTION BIOLOGY
fascicolo: 2, volume: 6, anno: 2001,
pagine: 129 - 136
SICI:
1355-6215(200104)6:2<129:EOCASI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING INHIBITOR RECEPTOR; GABA-A RECEPTOR; ELEVATED PLUS-MAZE; PREGNENOLONE SYNTHESIS; D-CYCLOSERINE; BRAIN; DIAZEPAM; STEROIDOGENESIS; MITOCHONDRIA; STIMULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Farges, RC Univ Fed Santa Catarina, Dept Farmacol, Ctr Ciencias Biol, Rua Ferreira Lima 82, BR-88015420 Florianopolis, SC, Brazil Univ Fed Santa Catarina Rua Ferreira Lima 82 Florianopolis SC Brazil BR-88015420 BC
Citazione:
G.S. Morato et al., "Effects of central and systemic injections of peripheral benzodiazepine receptor ligands on the anxiolytic actions of ethanol in rats", ADDICT BIOL, 6(2), 2001, pp. 129-136

Abstract

The influence of peripheral benzodiazepine receptor ligands Ro5-4864 (0.05or 1.0 mg/kg, i.p.) or PK11195 (0.05 or 1.0 mg/kg, i.p.) on the anxiolyticeffect of ethanol (1.2 g/kg; 14% p/v; i.p.) was investigated in rats tested on the elevated plus-maze. Other animals were injected through intrahippocampal administrations of the ligands (0.5 or 1.0 nmol/0.5 mul) before ethanol (1.2 g/kg; 14% p/v; i.p) and submitted to the elevated plus-maze test. The results showed that the systemic administration of either ligands 24 hours before the ethanol treatment resulted in a reduced anxiolytic effect ofthis drug. Only PK11195 reversed the effect of ethanol after intrahippocampal injection. These data suggest that peripheral benzodiazepine receptors plays a role in ethanol anxiolysis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:19:37