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Titolo:
New directions in the genetic mechanisms underlying nicotine addiction
Autore:
Munafo, M; Johnstone, E; Murphy, M; Walton, R;
Indirizzi:
Univ Oxford, Inst Hlth Sci, GPRG, Imperial Canc Res Fund, Oxford OX3 7LF, England Univ Oxford Oxford England OX3 7LF anc Res Fund, Oxford OX3 7LF, England
Titolo Testata:
ADDICTION BIOLOGY
fascicolo: 2, volume: 6, anno: 2001,
pagine: 109 - 117
SICI:
1355-6215(200104)6:2<109:NDITGM>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN TRANSPORTER GENE; CIGARETTE-SMOKING; RECEPTOR GENE; SENSATION SEEKING; OPIATE WITHDRAWAL; SMOKERS; ASSOCIATION; PERSONALITY; DEPENDENCE; DOPAMINE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Munafo, M Univ Oxford, Inst Hlth Sci, GPRG, Imperial Canc Res Fund, OxfordOX3 7LF, England Univ Oxford Oxford England OX3 7LF nd, Oxford OX3 7LF, England
Citazione:
M. Munafo et al., "New directions in the genetic mechanisms underlying nicotine addiction", ADDICT BIOL, 6(2), 2001, pp. 109-117

Abstract

Major advances have been made in understanding nicotine addiction and smoking behaviour in recent years. In particular, evidence for the relative importance of genetic and environmental effects on smoking initiation and persistence has emerged from behaviour genetic studies. These data have supported evidence from molecular genetic studies for the role of particular candidate genes in tobacco dependence. Studies of the personality correlates of smoking behaviour suggest that these factors mediate the association between genetics and smoking initiation, while learning models of nicotine addiction suggest a role for dopaminergic genes in facilitating neuroadaptations associated with smoking persistence and development of nicotine dependence. Integrating these different avenues of research represents one of the mostinteresting and potentially fruitful ventures in the treatment of tobacco dependence.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:29:30