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Titolo:
Agranulocytosis in a schizophrenic child receiving clozapine therapy - clinical picture and therapy. a case report
Autore:
Reitzle, K; Warnke, A; Wewetzer, C; Muller, H;
Indirizzi:
Univ Wurzburg, Klin Kinder & Jugendpsychiat & Psychotherapie, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 erapie, D-97080 Wurzburg, Germany Univ Wurzburg, Kinderklin, D-8700 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-8700 nderklin, D-8700 Wurzburg, Germany
Titolo Testata:
ZEITSCHRIFT FUR KINDER-UND JUGENDPSYCHIATRIE UND PSYCHOTHERAPIE
fascicolo: 2, volume: 29, anno: 2001,
pagine: 137 - 143
SICI:
1422-4917(200105)29:2<137:AIASCR>2.0.ZU;2-4
Fonte:
ISI
Lingua:
GER
Soggetto:
COLONY-STIMULATING FACTOR; GRANULOCYTE;
Keywords:
clozapine treatment; clozapine-induced agranulocytosis; childhood schizophrenia; case report;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Warnke, A Univ Wurzburg, Klin Kinder & Jugendpsychiat & Psychotherapie, Fuchsleinstr15, D-97080 Wurzburg, Germany Univ Wurzburg Fuchsleinstr 15 Wurzburg Germany D-97080 Germany
Citazione:
K. Reitzle et al., "Agranulocytosis in a schizophrenic child receiving clozapine therapy - clinical picture and therapy. a case report", Z KIND JUG, 29(2), 2001, pp. 137-143

Abstract

Objectives: The indication of clozapine therapy is governed by special guidelines due to a 1%-3 % risk of clozapine-induced agranulocytosis, Up to now there has never been a report of such a case in a child with schizophrenia. The case report presented here is concerned with the clinical features and the treatment of clozapine-induced agranulocytosis in childhood schizophrenia. Methods: It deals with the treatment of a 12-yearold boy with a schizophrenic psychosis. The psychotic symp toms before treatment and during inpatient treatment are described. The procedures for the diagnosis and treatment of the clozapine-induced agranulocytosis are presented. Results: Clozapine medication may induce agranulocytosis in the treatment of a child with a schizophrenic psychosis. The highly specific guidelines governing its use must be followed as well in the treatment of very early onset schizophrenia, An agranulocytosis may result following 15 weeks of clozapine medication. The treatment with granulocyte colony-stimulating factor seems to support normalization of the blood picture.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 00:53:11