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Titolo:
Triple marker screening for fetal chromosomal abnormalities in Korean women of advanced maternal age
Autore:
Kim, SK; Bai, SW; Chung, JE; Jung, YN; Park, KH; Cho, DJ; Kim, JW; Yang, YH; Song, CH;
Indirizzi:
Yonsei Univ, Coll Med, Dept Obstet & Gynecol, Seoul 120752, South Korea Yonsei Univ Seoul South Korea 120752 Gynecol, Seoul 120752, South Korea
Titolo Testata:
YONSEI MEDICAL JOURNAL
fascicolo: 2, volume: 42, anno: 2001,
pagine: 199 - 203
SICI:
0513-5796(200104)42:2<199:TMSFFC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERUM ALPHA-FETOPROTEIN; HUMAN CHORIONIC-GONADOTROPIN; UNCONJUGATED ESTRIOL; DOWNS-SYNDROME; HCG; AMNIOCENTESIS; PREGNANCIES; OLDER;
Keywords:
triple marker screening; chromosomal abnormalities; advanced maternal age;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, SK Yonsei Univ, Coll Med, Dept Obstet & Gynecol, CPO Box 8044, Seoul 120752, South Korea Yonsei Univ CPO Box 8044 Seoul South Korea 120752 52, South Korea
Citazione:
S.K. Kim et al., "Triple marker screening for fetal chromosomal abnormalities in Korean women of advanced maternal age", YONSEI MED, 42(2), 2001, pp. 199-203

Abstract

The purpose of this article is to assess the value of maternal serum triple marker screening of alpha-fetoprotein (AFP), human chorionic gonadotropin(hCG), and unconjugated estriol (uE(3)) for the prenatal diagnosis of fetal chromosomal abnormalities in Korean women of advanced maternal age. Maternal sera were collected from 458 pregnant Korean women aged 35 between 15 and 20 weeks gestation before amniocentesis. A patient- specific second trimester risk for fetal Down's syndrome was calculated using the median valuesfor AFP, hCG, uE(3) and maternal age. Twelve fetal chromosomal abnormalities were identified. These included six cases of trisomy 21, one case of 46,XY/47,XY,+21, two cases of trisomy 18, one case of trisomy 13, and two cases of 45, X. A cutoff level of 1:200 detected 85.7% (6/7) of the cases of Down's syndrome and 20% (1/5) of the other aneuploidies, with a 27.3% false positive rate. However, a cutoff level of 1:270 did not result in any gains in detecting Down's syndrome or other aneuploidies at the expense of a false positive rate of 34.3%, Second trimester triple marker resting is an effective screening tool for detecting fetal Down's syndrome in Korean women greater than or equal to 35 years old. However, it is not an effective screening tool for non-Down's chromosomal abnormalities.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 11:47:52