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Titolo:
Entopeduncular lesions facilitate and thalamic lesions depress spontaneousand drug-evoked motor behavior in the hemiparkinsonian rat
Autore:
Olds, ME; Jacques, DB; Kopyov, O;
Indirizzi:
CALTECH, Div Biol, Pasadena, CA 91125 USA CALTECH Pasadena CA USA 91125CALTECH, Div Biol, Pasadena, CA 91125 USA Hosp Good Samaritan, Inst Neurosci, Los Angeles, CA 90017 USA Hosp Good Samaritan Los Angeles CA USA 90017 i, Los Angeles, CA 90017 USA
Titolo Testata:
SYNAPSE
fascicolo: 3, volume: 40, anno: 2001,
pagine: 215 - 224
SICI:
0887-4476(20010601)40:3<215:ELFATL>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBTHALAMIC NUCLEUS; BASAL GANGLIA; FUNCTIONAL-ANATOMY; GLOBUS-PALLIDUS; SUBSTANTIA-NIGRA; APOMORPHINE; AMPHETAMINE; RESPONSES; PRIMATE; PARKINSONISM;
Keywords:
dopamine; entopeduncular nucleus; rotation; substantia nigra; thalamus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Olds, ME CALTECH, Div Biol, 156-29, Pasadena, CA 91125 USA CALTECH 156-29 Pasadena CA USA 91125 6-29, Pasadena, CA 91125 USA
Citazione:
M.E. Olds et al., "Entopeduncular lesions facilitate and thalamic lesions depress spontaneousand drug-evoked motor behavior in the hemiparkinsonian rat", SYNAPSE, 40(3), 2001, pp. 215-224

Abstract

Pallidotomy is a neurosurgical procedure designed to ameliorate the akinesia and bradykinesia associated with Parkinson's disease. In the present study, the effects of pallidal-like lesions on motor behavior in the hemiparkinsonian rat were compared to the effects of lesions in the ventrolateral thalamus, a target of entopeduncular projections feeding motor-related information to motor cortex. Six aspects of spontaneous and evoked behavior induced by amphetamine and apomorphine in the hemiparkinsonian rat with either bilateral electrolytic entopeduncular lesions or bilateral electrolytic ventrolateral thalamic lesions were measured for 60 min. Saline or amphetamine,5 mg/kg, or apomorphine, 0.3 mg/kg, were administered IP 5 min before the tests. The results show that on all measures except time spent resting the hemiparkinsonian rats with the entopeduncular lesions were more active thanthe hemiparkinsonian rats with the thalamic lesions. The asymmetrical rotation responses to dopamine receptor stimulation evoked by amphetamine and apomorphine were influenced by the general effect on gross motor behavior, as shown by the response being very large in the entopeduncular group and very small in the thalamic group. These results are consistent with current thinking about the functional organization of the basal ganglia according towhich damage of the entopeduncular nucleus reduces its inhibitory control of the thalamic motor regions, thereby promoting thalamic facilitation of motor cortex, and damage to the thalamic motor regions has the opposite effect. These effects of the lesions translate, respectively, into hyperactivity and hypoactivity without blocking the asymmetrical rotation response of the hemiparkinsonian rat. Synapse 40:215-224, 2001. (C) 2001 Wiley-Liss. Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 22:40:17