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Titolo:
Vesicular acetylcholine transporter in the rat nucleus accumbens shell: Subcellular distribution and association with mu-opioid receptors
Autore:
Svingos, AL; Colago, EEO; Pickel, VM;
Indirizzi:
Cornell Univ, Weill Med Coll, Dept Neurol & Neurosci, Div Neurobiol, New York, NY 10021 USA Cornell Univ New York NY USA 10021 Div Neurobiol, New York, NY 10021 USA
Titolo Testata:
SYNAPSE
fascicolo: 3, volume: 40, anno: 2001,
pagine: 184 - 192
SICI:
0887-4476(20010601)40:3<184:VATITR>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-LASTING CHANGES; CHOLINERGIC NEURONS; IMMUNOCYTOCHEMICAL LOCALIZATION; EXTRACELLULAR ACETYLCHOLINE; MEDIATED INHIBITION; SYNAPTIC VESICLES; SUBSTANTIA-NIGRA; DOPAMINE NEURONS; NERVE-TERMINALS; CELL-BODIES;
Keywords:
cholinergic; striatum; ultrastructure; opiate; morphine; dendritic release;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Svingos, AL Cornell Univ, Weill Med Coll, Dept Neurol & Neurosci, Div Neurobiol, 411 E69th St, New York, NY 10021 USA Cornell Univ 411 E 69th St New York NY USA 10021 NY 10021 USA
Citazione:
A.L. Svingos et al., "Vesicular acetylcholine transporter in the rat nucleus accumbens shell: Subcellular distribution and association with mu-opioid receptors", SYNAPSE, 40(3), 2001, pp. 184-192

Abstract

Cholinergic interneurons in the nucleus accumbens shell (AcbSh) are implicated in the reinforcing behaviors that develop in response to opiates active at mu -opioid receptors (MOR). We examined the electron microscopic immunocytochemical localization of the vesicular acetylcholine transporter (VAChT) and MOR to determine the functional sites for storage and release of acetylcholine (ACh), and potential interactions involving MOR in this region of rat brain. VAChT was primarily localized to membranes of small synaptic vesicles in axon terminals. Less than 10% of the VAChT-labeled terminals were MOR-immunoreactive. In contrast, 35% of the cholinergic terminals formed symmetric or punctate synapses with dendrites showing an extrasynaptic plasmalemmal distribution of MOR. Membranes of tubulovesicles in other selective dendrites were also VAChT-labeled, and almost half of these dendrites displayed plasmalemmal MOR immunoreactivity. The VAChT-labeled dendritic tubulovesicles often apposed unlabeled axon terminals that formed symmetric synapses. Our results indicate that in the AcbSh MOR agonists can modulate the release of ACh from vesicular storage sites in axon terminals as well as indendrites where the released ACh may serve an autoregulatory function involving inhibitory afferents. These results also suggest, however, that many of the dendrites of spiny projection neurons in the AcbSh are dually influenced by ACh and opiates active at MOR, thus providing a cellular substrate for ACh in the reinforcement of opiates. Synapse 40:184-192, 2001. (C) 2001Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 08:15:41