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Titolo:
Neuronal BC1 RNA structure: Evolutionary conversion of a tRNA(Ala) domain into an extended stem-loop structure
Autore:
Rozhdestvensky, TS; Kopylov, AM; Brosius, J; Huttenhofer, A;
Indirizzi:
Inst Expt Pathol Mol Neurobiol, D-48149 Munster, Germany Inst Expt Pathol Mol Neurobiol Munster Germany D-48149 Munster, Germany Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119899, Russia Moscow MVLomonosov State Univ Moscow Russia 119899 oscow 119899, Russia
Titolo Testata:
RNA-A PUBLICATION OF THE RNA SOCIETY
fascicolo: 5, volume: 7, anno: 2001,
pagine: 722 - 730
SICI:
1355-8382(200105)7:5<722:NBRSEC>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
BC200 RNA; HIPPOCAMPAL-NEURONS; DENDRITIC LOCATION; ESCHERICHIA-COLI; MASTER GENE; DNA; AMPLIFICATION; EXPRESSION; POLYMERASE; ELEMENTS;
Keywords:
BC1 RNA; chemical probing; ID elements; neuronaI dendritic RNA; secondary structure; tRNA ancestor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Brosius, J Inst Expt Pathol Mol Neurobiol, Von Esmarch Str 56, D-48149 Munster, Germany Inst Expt Pathol Mol Neurobiol Von Esmarch Str 56 Munster Germany D-48149
Citazione:
T.S. Rozhdestvensky et al., "Neuronal BC1 RNA structure: Evolutionary conversion of a tRNA(Ala) domain into an extended stem-loop structure", RNA, 7(5), 2001, pp. 722-730

Abstract

By chemical and enzymatic probing, we have analyzed the secondary structure of rodent BC1 RNA, a small brain-specific non-messenger RNA. BC1 RNA is specifically transported into dendrites of neuronal cells, where it is proposed to play a role in regulation of translation near synapses. In this study we demonstrate that the 5' domain of BC1 RNA, derived from tRNA(Ala), does not fold into the predicted canonical tRNA cloverleaf structure. We present evidence that by changing bases within the tRNA(Ala) domain during the course of evolution, an extended stem-loop structure has been created in BC1RNA. The new structural domain might function, in part, as a putative binding site for protein(s) involved in dendritic transport of BC1 RNA within neurons. Furthermore, BC1 RNA contains, in addition to the extended stem-loop structure, an internal poly(A)-rich region that is supposedly single stranded, followed by a second smaller stem-loop structure at the 3' end of theRNA. The three distinct structural domains reflect evolutionary legacies of BC1 RNA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:56:19