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Titolo:
Pulmonary hypertension in systemic sclerosis: risk factors for progressionand consequences for survival
Autore:
MacGregor, AJ; Canavan, R; Knight, C; Denton, CP; Davar, J; Coghlan, J; Black, CM;
Indirizzi:
Royal Free Hosp, Dept Rheumatol, London NW3 2QG, England Royal Free Hosp London England NW3 2QG heumatol, London NW3 2QG, England Royal Free Hosp, Dept Cardiol, London NW3 2QG, England Royal Free Hosp London England NW3 2QG Cardiol, London NW3 2QG, England
Titolo Testata:
RHEUMATOLOGY
fascicolo: 4, volume: 40, anno: 2001,
pagine: 453 - 459
SICI:
1462-0324(200104)40:4<453:PHISSR>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CREST SYNDROME VARIANT; ARTERIAL-HYPERTENSION; SCLERODERMA; PREVALENCE; MORTALITY; DISEASE;
Keywords:
systemic sclerosis; echocardiography; vascular; morbidity; mortality;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: MacGregor, AJ St Thomas Hosp, Twin Res & Genet Epidemiol Unit, Lambeth Palace Rd, LondonSE1 7EH, England St Thomas Hosp Lambeth Palace Rd London England SE1 7EH and
Citazione:
A.J. MacGregor et al., "Pulmonary hypertension in systemic sclerosis: risk factors for progressionand consequences for survival", RHEUMATOLOG, 40(4), 2001, pp. 453-459

Abstract

Objective. To assess the rate of progression of pulmonary hypertension (PHT) in systemic sclerosis (SSc) and its bearing on mortality. Methods. A retrospective record review of 930 patients with SSc attending a specialist centre was carried out. Those at risk for both idiopathic and secondary PHT were assessed by serial Doppler echocardiography. Mortality data were reviewed. Results. The cumulative prevalence of PHT was 13%. Pressures remained static in most cases. The mortality among those with a single pressure reading of 30 mmHg or higher was 20% at 20 months. An increased mortality risk was associated with high initial pressures and rising pressures. Rapid pressurerises occurred more frequently in limited than in diffuse SSc. Conclusions. The prevalence of PHT in SSc is high and the detection of PHTat any time in the disease course is associated with substantial mortality. These results demonstrate the value of echocardiographic screening for PHT in all patients with SSc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 15:52:27