Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Decreased serum erythropoietin and its relation to anti-erythropoietin antibodies in anaemia of systemic lupus erythematosus
Autore:
Schett, G; Firbas, U; Fureder, W; Hiesberger, H; Winkler, S; Wachauer, D; Koller, M; Kapiotis, S; Smolen, J;
Indirizzi:
Univ Vienna, Sch Med, Div Rheumatol, Dept Internal Med 3, A-1180 Vienna, Austria Univ Vienna Vienna Austria A-1180 Internal Med 3, A-1180 Vienna, Austria Univ Vienna, Sch Med, Div Hematol, A-1180 Vienna, Austria Univ Vienna Vienna Austria A-1180 d, Div Hematol, A-1180 Vienna, Austria Univ Vienna, Sch Med, Div Infect Dis, Dept Internal Med 1, A-1180 Vienna, Austria Univ Vienna Vienna Austria A-1180 Internal Med 1, A-1180 Vienna, Austria Univ Vienna, Sch Med, Clin Anesthesia & Intens Care, A-1180 Vienna, Austria Univ Vienna Vienna Austria A-1180 & Intens Care, A-1180 Vienna, Austria Univ Vienna, Sch Med, Cent Lab Unit, Dept Lab Med, A-1180 Vienna, Austria Univ Vienna Vienna Austria A-1180 , Dept Lab Med, A-1180 Vienna, Austria
Titolo Testata:
RHEUMATOLOGY
fascicolo: 4, volume: 40, anno: 2001,
pagine: 424 - 431
SICI:
1462-0324(200104)40:4<424:DSEAIR>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECOMBINANT-HUMAN-ERYTHROPOIETIN; ANTIERYTHROPOIETIN ANTIBODIES; RHEUMATOID-ARTHRITIS; CHRONIC DISEASE; ANEMIA; PATIENT; PROLIFERATION; THERAPY;
Keywords:
SLE; anaemia; erythropoietin; anti-erythropoietin antibodies;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Schett, G Univ Vienna, Sch Med, Div Rheumatol, Dept Internal Med 3, Wahringer Gurtel18-20, A-1180 Vienna, Austria Univ Vienna Wahringer Gurtel 18-20 Vienna Austria A-1180 ustria
Citazione:
G. Schett et al., "Decreased serum erythropoietin and its relation to anti-erythropoietin antibodies in anaemia of systemic lupus erythematosus", RHEUMATOLOG, 40(4), 2001, pp. 424-431

Abstract

Objective. This study was performed to assess erythropoietin levels and anti-erythropoietin antibodies in patients with systemic lupus erythematosus (SLE). Methods. The sera of 100 patients with SLE were investigated for serum erythropoietin levels and the presence of anti-erythropoietin antibodies by ELISA. Routine laboratory parameters such as peripheral blood count, relevantparameters of blood chemistry, and immunological parameters of SLE were recorded. Results. Erythropoietin levels were significantly decreased in SLE patients when related to individual haemoglobin and haematocrit values (P <0.001),suggesting an inadequate erythropoietin response in SLE. Anti-erythropoietin antibodies were found in 46% of SLE patients. and erythropoietin levels (but not haemoglobin or haematocrit values were significantly decreased in these patients compared with patients without anti-erythropoietin antibodies. Serum erythropoietin concentration as determined by ELISA was reduced inthe presence of anti-erythropoietin antibodies. Furthermore. anti-erythropoietin antibodies also correlated with younger age, decreased serum levels of complement factors C3 and C4 and elevated anti-double-stranded DNA antibodies. Conclusions. We conclude that the anaemia of SLE is characterized by an inadequate erythropoietin response. Anti-erythropoietin antibodies are frequently present in SLE and interfere with the measurement of serum erythropoietin level. However, these antibodies are not associated with increased severity of SLE-associated anaemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 14:19:05