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Titolo:
Infralimbic muscarinic M1 receptors modulate anxiety-like behaviour and spontaneous working memory in mice
Autore:
Wall, PM; Flinn, J; Messier, C;
Indirizzi:
Univ Ottawa, Sch Psychol, Ottawa, ON K1N 6N5, Canada Univ Ottawa Ottawa ON Canada K1N 6N5 Psychol, Ottawa, ON K1N 6N5, Canada
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 1, volume: 155, anno: 2001,
pagine: 58 - 68
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELEVATED PLUS-MAZE; MEDIAL PREFRONTAL CORTEX; SPONTANEOUS-ALTERNATION PERFORMANCE; BASAL FOREBRAIN LESIONS; INDUCED DELAYED AMNESIA; DOUBLE Y-MAZE; NEUROPSYCHIATRIC DISORDERS; CHOLINERGIC SYSTEMS; DORSAL HIPPOCAMPUS; REDUCES ANXIETY;
Keywords:
concurrent modulation; anxiety-like behaviour; spontaneous working memory; infralimbic prefrontal cortex; muscarinic receptor; elevated plus-maze; Y-maze;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Wall, PM Univ Ottawa, Sch Psychol, Ottawa, ON K1N 6N5, Canada Univ OttawaOttawa ON Canada K1N 6N5 Ottawa, ON K1N 6N5, Canada
Citazione:
P.M. Wall et al., "Infralimbic muscarinic M1 receptors modulate anxiety-like behaviour and spontaneous working memory in mice", PSYCHOPHAR, 155(1), 2001, pp. 58-68

Abstract

Rationale: Spontaneous working memory and anxiety-like behaviour can be concurrently influenced following kappal opioid agonist or antagonist infusions in the infralimbic (IL) area of the ventromedial prefrontal cortex (vmPFC) in CD-1 mice. Objective: The present study sought to evaluate whether acetylcholine (ACh) muscarinic (M) receptor drugs can similarly influence these cognitive-behavioural processes in the IL cortex. Method: Anxiety was evaluated in the elevated plus-maze and spontaneous working memory was evaluated in the Y-maze following scopolamine, pirenzepine or McN-A-343 infusion in the IL cortex. Results: In experiment 1, the non-specific muscarinic receptor antagonist, scopolamine, was anxiogenic in trial 1 (5, 10 and 20 nmol), but did not influence behaviour in trial 2 (no-injection) in the elevated plus-maze 24 h later. In week 2, scopolamine disrupted spontaneous working memory in the Y-maze at the highest dose (20 nmol). In experiment 2, pretreatment with the M1 antagonist, pirenzepine, was anxiolytic in trial 1 (5 and 10 nmol), as well as in trial 2 (no-injection) in the elevated plus-maze 24 h late (0.25, 1.25, 2.5, 5 and 10 nmol). In week 2, pirenzepine disrupted spontaneous working memory in the Y-maze (2.5, 5 and 10 nmol). In experiment 3, pretreatment with the M1 agonist, McN-A-343, was anxiogenic in trial 1 (2.5, 5, 10 and 20 nmol), as well as in trial 2 (no-injection) in the elevated plus-maze 24 h later (2.5, 5, 10 and 20 nmol). In week 2, McN-A-343 enhanced spontaneous working memory in the Y-maze (2.5, 5, 10 and 20 nmol). Conclusions: (1) Enhanced ACh transmission in the vmPFC induces anxiety in challenging environments and enhances spontaneous working memory performance. (2) Blocking or activating postsynaptic M1 receptors in the vmPFC maytruncate or exaggerate, respectively, afferent anxiety-relevant information. (3) IL pirenzepine and McN-A-343 exert long-term opposite effects on aversive learning during trial 1 in the elevated plus-maze.

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Documento generato il 28/10/20 alle ore 17:44:38