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Titolo:
Pretreatment with glucose increases entry of urocortin into mouse brain
Autore:
Kastin, AJ; Akerstrom, V;
Indirizzi:
Vet Adm Med Ctr, New Orleans, LA 70112 USA Vet Adm Med Ctr New Orleans LAUSA 70112 d Ctr, New Orleans, LA 70112 USA Tulane Univ, Sch Med, New Orleans, LA 70112 USA Tulane Univ New Orleans LA USA 70112 , Sch Med, New Orleans, LA 70112 USA
Titolo Testata:
PEPTIDES
fascicolo: 5, volume: 22, anno: 2001,
pagine: 829 - 834
SICI:
0196-9781(200105)22:5<829:PWGIEO>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBESE GENE-EXPRESSION; FOOD-INTAKE; ENTERS BRAIN; LEPTIN; BLOOD; INSULIN; TRANSPORT; BARRIER; NEUROPEPTIDE; STIMULATION;
Keywords:
urocortin; blood-brain barrier; glucose; insulin; streptozotocin; satiety; peptide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Kastin, AJ Vet Adm Med Ctr, New Orleans, LA 70112 USA Vet Adm Med Ctr NewOrleans LA USA 70112 Orleans, LA 70112 USA
Citazione:
A.J. Kastin e V. Akerstrom, "Pretreatment with glucose increases entry of urocortin into mouse brain", PEPTIDES, 22(5), 2001, pp. 829-834

Abstract

Although urocortin is a potent inhibitor of food ingestion after peripheral administration. it was recently shown that under normal conditions this peptide crosses the blood-brain barrier (BBB) at a very slow rate. We examined whether hyperglycemia could stimulate the rate of entry (K-i) of I-125-urocortin into the mouse brain. In euglycemic mice, I-125-urocortin injectediv entered the brain at a rate similar to that of the vascular marker Tc-99m-albumin. However, injection of glucose (3 g/kg, ip) 0.5, 1, or 2 h before the I-125-urocortin greatly increased the influx of urocortin. Without the glucose, the self-inhibition characteristic of a saturable transport system was not apparent. Self-inhibition could be demonstrated after the glucose injection, indicating activation of a transport system for urocortin thatwas saturable. Injection of insulin (10 U/kg, ip) 1 or 2 h before the I-125-urocortin decreased the K-i. Thus, the entry of urocortin into brain can be activated by changes in the concentration of blood glucose, illustratingthe responsiveness of the BBB to regulatory influences. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 05:05:44