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Titolo:
Endometrial and myometrial corticotropin-releasing hormone (CRH): its regulation and possible roles
Autore:
Gravanis, A; Makrigiannakis, A; Zoumakis, E; Margioris, AN;
Indirizzi:
Univ Crete, Sch Med, Dept Pharmacol & Clin Chem, Heraklion 71110, Crete, Greece Univ Crete Heraklion Crete Greece 71110 m, Heraklion 71110, Crete, Greece
Titolo Testata:
PEPTIDES
fascicolo: 5, volume: 22, anno: 2001,
pagine: 785 - 793
SICI:
0196-9781(200105)22:5<785:EAMCH(>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
STROMAL CELL-DIFFERENTIATION; HUMAN-FETAL MEMBRANES; PROSTAGLANDIN E-2; GENE-EXPRESSION; IN-VITRO; EMBRYO IMPLANTATION; HUMAN PLACENTA; GROWTH-FACTOR; RECEPTOR; IDENTIFICATION;
Keywords:
CRH; uterus; decidualization; implantation; labour;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Gravanis, A Univ Crete, Sch Med, Dept Pharmacol & Clin Chem, Heraklion 71110, Crete, Greece Univ Crete Heraklion Crete Greece 71110 71110, Crete, Greece
Citazione:
A. Gravanis et al., "Endometrial and myometrial corticotropin-releasing hormone (CRH): its regulation and possible roles", PEPTIDES, 22(5), 2001, pp. 785-793

Abstract

In human endometrium, both epithelial and stroma cells produce corticotropin-releasing hormone (CRH). Both types of cells also possess specific CRH-binding sites indicating a local effect of endometrial CRH. The transcription of the CRH gene in human endometrium is under the control of steroid hormones and locally produced prostanoids and interleukins. Endometrial CRH interacts with locally produced prostaglandins and interleukins. Based on these observations it can be hypothesized that CRH, prostaglandins and interleukins form a network responsible for the communication between epithelial and stromal cells. at the level of the endometrium, and between endometrial and myometrial cells at the level of uterus. The net product of these interaction is the micro-regulation of the decidualizing process and the preparation of endometrium for the implantation/nidation of the conceptus. Indeed. this network may represent the core of the intrauterine neuroendocrine-immune interactions involved in the decidualization of stroma and implantation of blastocyst. In addition, this network appears to be essential for the fine-tuning of myometrial tone. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 09:55:17