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Titolo:
Regulation of pituitary corticotropin releasing hormone receptors
Autore:
Aguilera, G; Rabadan-Diehl, C; Nikodemova, M;
Indirizzi:
NICHD, Dev Endocrinol Branch, Sect Endocrine Physiol, NIH, Bethesda, MD 20892 USA NICHD Bethesda MD USA 20892 ndocrine Physiol, NIH, Bethesda, MD 20892 USA
Titolo Testata:
PEPTIDES
fascicolo: 5, volume: 22, anno: 2001,
pagine: 769 - 774
SICI:
0196-9781(200105)22:5<769:ROPCRH>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RIBONUCLEIC-ACID; FACTOR CRF RECEPTORS; HOMOLOGOUS DESENSITIZATION; GLUCOCORTICOID REGULATION; ARGININE-VASOPRESSIN; ACTH-SECRETION; DEFICIENT MICE; CHRONIC STRESS; RAT PITUITARY; ADRENAL AXIS;
Keywords:
corticotropin releasing hormone receptor type-1 pituitary; CRH receptor binding; CRH receptor mRNA; CRH receptor regulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Aguilera, G NICHD, Dev Endocrinol Branch, Sect Endocrine Physiol, NIH, Bethesda, MD 20892 USA NICHD Bethesda MD USA 20892 siol, NIH, Bethesda, MD 20892 USA
Citazione:
G. Aguilera et al., "Regulation of pituitary corticotropin releasing hormone receptors", PEPTIDES, 22(5), 2001, pp. 769-774

Abstract

Corticotropin releasing hormone (CRH) stimulates pituitary ACTH secretion through type-1 CRH (CRH1) receptors. Stimulation of the hypothalamic pituitary adrenal (HPA) axis as well as increased corticotroph responsiveness during stress and adrenalectomy are associated with marked pituitary CRH binding downregulation. The presence of CRH1 receptors in the pituitary are essential to maintain ACTH secretion. Downregulation of CRH binding is associated with normal or elevated levels of CRH1 receptor mRNA and this may contribute to the maintainence of permissive levels of CRH I receptors in the pituitary. Injection of either CRH or glucocorticoids in rats in vivo induces CRH binding and CRH1 receptor mRNA downregulation, whereas their simultaneous administration causes only transient CRH1 receptor mRNA loss. Vasopressin increases CRH1 receptor mRNA levels. This suggest that interactions between CRH, vasopressin and glucocorticoids accounts for CRH1 receptor mRNA upregulation during stress. The lack of correlation between CRH binding and CRH1 receptor mRNA indicates that the major sites for pituitary CRH1 receptorregulation are at the post-transcriptional level. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 00:19:28