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Titolo:
Corticotropin-releasing hormone and its receptors: an evaluation at the transcription level in vivo
Autore:
Drolet, G; Rivest, S;
Indirizzi:
CHU Laval, Res Ctr, Mol Endocrinol Lab, Quebec City, PQ G1V 4G2, Canada CHU Laval Quebec City PQ Canada G1V 4G2 , Quebec City, PQ G1V 4G2, Canada CHU Laval, Res Ctr, Neurosci Unit, Quebec City, PQ G1V 4G2, Canada CHU Laval Quebec City PQ Canada G1V 4G2 , Quebec City, PQ G1V 4G2, Canada Univ Laval, Quebec City, PQ G1V 4G2, Canada Univ Laval Quebec City PQ Canada G1V 4G2 Quebec City, PQ G1V 4G2, Canada
Titolo Testata:
PEPTIDES
fascicolo: 5, volume: 22, anno: 2001,
pagine: 761 - 767
SICI:
0196-9781(200105)22:5<761:CHAIRA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RIBONUCLEIC-ACID; FACTOR CRF RECEPTOR; PARAVENTRICULAR NUCLEUS; RAT HYPOTHALAMUS; C-FOS; IMMOBILIZATION STRESS; NEURONAL-ACTIVITY; IMMUNE CHALLENGE; GENE-EXPRESSION; ACTH RELEASE;
Keywords:
hypothalamus; hnRNA; immune response; stress; rats; glucocorticoids;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Rivest, S CHU Laval, Res Ctr, Mol Endocrinol Lab, 2705 Blvd Laurier, Quebec City, PQG1V 4G2, Canada CHU Laval 2705 Blvd Laurier Quebec City PQ CanadaG1V 4G2 Canada
Citazione:
G. Drolet e S. Rivest, "Corticotropin-releasing hormone and its receptors: an evaluation at the transcription level in vivo", PEPTIDES, 22(5), 2001, pp. 761-767

Abstract

Activation of the hypothalamic-pituitary-adrenal (HPA) axis is the main defining feature of the stress response. The primary mediator of this response is corticotropin-releasing hormone (CRH), a 41-residue peptide acknowledged as the principal hypophysiotropic factor driving stress-induced adrenocorticotropic hormone (ACTH) secretion. Although CRH is widely distributed within the central nervous system (CNS). the paraventricular nucleus (PVN) ofthe hypothalamus is the principal site of the parvocellular neurosecretoryneurons responsible for delivering CRH to the hypophyseal portal system, an event that initiates the activity of the pituitary-adrenal axis. Stress-induced transcriptional activation of CRH takes place quite uniquely in thishypothalamic nucleus, despite the robust constitutive hybridization signalfor CRH mRNA across the brain. The fact that CRH itself is capable of mimicking these effects and that de novo but transient expression of its type one receptor occurs in the PVN are data that make this hypothalamic region of great interest to study the mechanisms that lead to such specific transcriptional activity. This review will present evidence of such phenomenon by stressors of different categories as well as the possible neuromediators involved. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 02:53:54