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Titolo:
Molecular biology of the CRH receptors - in the mood
Autore:
Dautzenberg, FM; Kilpatrick, GJ; Hauger, RL; Moreau, JL;
Indirizzi:
F Hoffmann La Roche & Co Ltd, Div Pharma, CH-4070 Basel, Switzerland F Hoffmann La Roche & Co Ltd Basel Switzerland CH-4070 asel, Switzerland CeNeS Ltd, Cambridge CB4 9ZR, England CeNeS Ltd Cambridge England CB4 9ZR eNeS Ltd, Cambridge CB4 9ZR, England Univ Calif San Diego, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 Diego, La Jolla, CA 92093 USA Vet Adm Med Ctr, Dept Psychiat, La Jolla, CA 92093 USA Vet Adm Med Ctr LaJolla CA USA 92093 pt Psychiat, La Jolla, CA 92093 USA
Titolo Testata:
PEPTIDES
fascicolo: 5, volume: 22, anno: 2001,
pagine: 753 - 760
SICI:
0196-9781(200105)22:5<753:MBOTCR>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-FACTOR; IMPAIRED STRESS-RESPONSE; HORMONE RECEPTOR-2; LIGAND-BINDING; HIGH-AFFINITY; UROTENSIN-I; RAT-BRAIN; PHARMACOLOGICAL CHARACTERIZATION; FUNCTIONAL EXPRESSION; TUPAIA-BELANGERI;
Keywords:
corticotropin-releasing hormone; CRH receptor; alternative splicing; CRH binding pocket; CRH receptor deficient mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Dautzenberg, FM F Hoffmann La Roche & Co Ltd, Div Pharma, Grensacher Str 124, CH-4070 Basel, Switzerland F Hoffmann La Roche & Co Ltd Grensacher Str 124 Basel Switzerland CH-4070
Citazione:
F.M. Dautzenberg et al., "Molecular biology of the CRH receptors - in the mood", PEPTIDES, 22(5), 2001, pp. 753-760

Abstract

Dysfunctioning of corticotropin-releasing hormone (CRH) and its receptors (CRH1 and CRH2) has been linked to the development of stress-related disorders. such as mood and eating disorders. The molecular characterization of CRH1 and CRH2 receptors and their splice variants has generated detailed information on their pharmacology, tissue distribution and physiology. While mammalian CRH1 receptors nonselectively bind CRH analogs. the ligand specificity of CRH2 is narrower. CRH1 receptors are predominantly expressed in thebt ain and pituitary, whereas CRH2 receptor expression is limited to particular brain areas and to some peripheral organs. Molecular approaches to block CRH1 receptor expression in the brain argue in favor of its involvementin the regulation of some aspects of the stress response. The CRH2 alpha receptor may be more important for motivational types of behavior essential for survival, such as feeding and defense. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/02/20 alle ore 21:05:59