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Titolo:
High prevalence of eosinophilia in growth hormone-deficient children
Autore:
Kawada, Y; Yamamoto, Y; Noda, M; Asayama, K; Shirahata, A;
Indirizzi:
Univ Occupat & Environm Hlth, Sch Med, Dept Pediat, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan Univ Occupat & Environm Hlth Kitakyushu Fukuoka Japan 8078555 8555, Japan
Titolo Testata:
PEDIATRICS INTERNATIONAL
fascicolo: 2, volume: 43, anno: 2001,
pagine: 141 - 145
SICI:
1328-8067(200104)43:2<141:HPOEIG>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-I; IMMUNE FUNCTION; SHORT STATURE; SYSTEM;
Keywords:
adolescents; allergic disorders; child; eosinophilia; growth hormone deficiency;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Kawada, Y Univ Occupat & Environm Hlth, Sch Med, Dept Pediat, Yahatanishi Ku, 1-1 Iseigaoka, Kitakyushu, Fukuoka 8078555, Japan Univ Occupat & Environm Hlth 1-1 Iseigaoka Kitakyushu Fukuoka Japan 8078555
Citazione:
Y. Kawada et al., "High prevalence of eosinophilia in growth hormone-deficient children", PEDIATR INT, 43(2), 2001, pp. 141-145

Abstract

Background: To determine the clinical significance of eosinophilia in growth-hormone (GH)-deficient children, a clinical study consisting of 72 children and adolescents (mean age 9 years and 6 months at diagnosis) with GH deficiency (GHD) was undertaken. Patients were treated with GH, along with supplementation for the combined deficiency in patients with multiple hormonedeficiency. Methods: a complete blood count and hemogram with microscopic examination of a peripheral blood smear was performed. Results: Before treatment, differential eosinophil counts exceeded 5% in 30 subjects (41.7%) and absolute eosinophil counts were > 350/muL in 27 subjects (37.5%). Growth hormone therapy did not significantly affect eosinophil counts. There was an inverse relationship between absolute eosinophil count and peak GH value in response to the L-dopa stimulation test (n = 65; R-s = -0.252; P = 0.044). Conclusions: For the diagnosis of GHD, one should take into account that GH response to L-dopa stimulation can be selectively blunted in patients with eosinophilia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:39:56