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Titolo:
Autoimmune disease-associated lymphadenopathy with histological appearanceof T-zone dysplasia with hyperplastic follicles. A clinicopathological analysis of nine cases
Autore:
Kojima, M; Nakamura, S; Oyama, T; Motoori, T; Itoh, H; Yoshida, K; Suchi, T; Masawa, N;
Indirizzi:
Dokkyo Univ, Sch Med, Dept Pathol 1, Mibu, Tochigi 3210293, Japan Dokkyo Univ Mibu Tochigi Japan 3210293 ol 1, Mibu, Tochigi 3210293, Japan Aichi Canc Ctr Hosp, Dept Pathol & Genet, Nagoya, Aichi, Japan Aichi Canc Ctr Hosp Nagoya Aichi Japan hol & Genet, Nagoya, Aichi, Japan Gunma Univ, Sch Med, Dept Pathol 2, Maebashi, Gumma, Japan Gunma Univ Maebashi Gumma Japan d, Dept Pathol 2, Maebashi, Gumma, Japan Kitasato Med Ctr Hosp, Dept Pathol, Kitamoto, Japan Kitasato Med Ctr HospKitamoto Japan Hosp, Dept Pathol, Kitamoto, Japan Maebashi Red Cross Hosp, Dept Pathol, Maebashi, Gumma, Japan Maebashi Red Cross Hosp Maebashi Gumma Japan hol, Maebashi, Gumma, Japan Kiryu Welf Gen Hosp, Dept Pathol, Kiryu, Gumma, Japan Kiryu Welf Gen HospKiryu Gumma Japan , Dept Pathol, Kiryu, Gumma, Japan Kiryu Welf Gen Hosp, Clin Labs, Kiryu, Gumma, Japan Kiryu Welf Gen Hosp Kiryu Gumma Japan sp, Clin Labs, Kiryu, Gumma, Japan Maebashi Red Cross Hosp, Clin Labs, Maebashi, Gumma, Japan Maebashi Red Cross Hosp Maebashi Gumma Japan abs, Maebashi, Gumma, Japan
Titolo Testata:
PATHOLOGY RESEARCH AND PRACTICE
fascicolo: 4, volume: 197, anno: 2001,
pagine: 237 - 244
SICI:
0344-0338(2001)197:4<237:ADLWHA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC-LUPUS-ERYTHEMATOSUS; ANGIO-IMMUNOBLASTIC LYMPHADENOPATHY; REACTIVE FOLLICULAR HYPERPLASIA; RHEUMATOID-ARTHRITIS; REVISED CRITERIA; GERMINAL-CENTERS; CELL LYMPHOMA; CLASSIFICATION; DIAGNOSIS; FEATURES;
Keywords:
autoimmune disease; systemic lupus erythematosus; lymph node; T-zone dysplasia with hyperplastic follicles; hyperimmune reaction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Kojima, M Dokkyo Univ, Sch Med, Dept Pathol 1, Mibu, Tochigi 3210293, Japan Dokkyo Univ Mibu Tochigi Japan 3210293 , Tochigi 3210293, Japan
Citazione:
M. Kojima et al., "Autoimmune disease-associated lymphadenopathy with histological appearanceof T-zone dysplasia with hyperplastic follicles. A clinicopathological analysis of nine cases", PATH RES PR, 197(4), 2001, pp. 237-244

Abstract

Autoimmune disease-associated lymphadenopathy shows marked histopathological and clinical diversity. We describe the clinicopathological and immunohistochemical findings of nine cases of autoimmune disease-associated lymphadenopathy, which posed a serious differential diagnostic problem regarding T-zone dysplasia with hyperplastic follicles. There were two males and sevenfemales aged 25 to 65 years (median 37 years). The patients had multicentric lymphadenopathy in association with clinical and laboratory findings suggestive of an "autoimmune disease". Four patients were diagnosed to have systemic lupus erythematosus (SLE), and the remaining five patients had antiphospholipid antibody syndrome and Sjogren's syndrome (SS), rheumatoid arthritis (RA), chronic thyroiditis, RA and SS, and SLE and SS, respectively. None of the nine patients developed malignant lymphomas during the follow-up periods from 44 to 225 months (median 103 months). The lesions were characterized by paracortical hyperplasia with prominent vascular proliferation and many lymphoid follicles with germinal centers. The paracortical area usually contained numerous small T-lymphocytes without cytological atypia, accompanied by a variable number of plasma cells, B-immunoblasts, and histiocytes. Polymerase chain reaction analysis demonstrated no clonal rearrangementof the T-cell receptor chain gene in four cases examined, although immunoglobulin heavy chain rearrangement was detected in only one case. These findings suggest that autoimmune disease-associated lymphadenopathy, especiallySLE, shares the histological features with T-zone dysplasia with hyperplastic follicles. The nine cases presented here should be differentiated from T-zone lymphoma with follicles and angioimmunoblastic lymphoma with hyperplastic germinal centers. To avoid overdiagnosis and overtreatment, we emphasize the need to turn attention to these clinical and laboratory findings aswell as to the morphological features.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 15:08:11