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Titolo:
The effect of monoclonal antibody and route of immunization on the humoralimmune response against Porphyromonas gingivalis
Autore:
van Tilburg, MLJA; Kozarov, EV; Progulske-Fox, A; Brady, LJ;
Indirizzi:
Univ Florida, Dept Oral Biol, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610 ral Biol, Gainesville, FL 32610 USA
Titolo Testata:
ORAL MICROBIOLOGY AND IMMUNOLOGY
fascicolo: 3, volume: 16, anno: 2001,
pagine: 153 - 162
SICI:
0902-0055(200106)16:3<153:TEOMAA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
DESTRUCTIVE PERIODONTAL-DISEASE; BLACK-PIGMENTED BACTEROIDES; ACTINOBACILLUS-ACTINOMYCETEMCOMITANS; PASSIVE-IMMUNIZATION; CRYPTOCOCCUS-NEOFORMANS; STREPTOCOCCUS-MUTANS; HUMAN-IMMUNOGLOBULIN; HEMAGGLUTININ GENE; VIRULENCE FACTORS; CREVICULAR FLUID;
Keywords:
Porphyromonas gingivalis; immunomodulation; mucosal immunization; murine; antibody-antigen complex; humoral immunity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Brady, LJ Univ Florida, Dept Oral Biol, JHMHC Box 100424, Gainesville, FL 32610 USA Univ Florida JHMHC Box 100424 Gainesville FL USA 32610 32610 USA
Citazione:
M.L.J.A. van Tilburg et al., "The effect of monoclonal antibody and route of immunization on the humoralimmune response against Porphyromonas gingivalis", ORAL MICROB, 16(3), 2001, pp. 153-162

Abstract

Immunomodulation mediated by exogenous antibodies has been proposed as a vaccine strategy to improve immune protection against pathogenic microorganisms and suggested to contribute to protection following passive immunization. To test whether a monoclonal antibody directed against an adhesion epitope of the periodontal pathogen Porphyromonas gingivalis could influence thehumoral immune response following mucosal immunization, BALB/c mice were immunized orally or intranasally with P, gingivalis alone or P. gingivalis coated with monoclonal antibody 61BG1.3. Differences in antigenic specificity of anti-P., gingivalis serum immunoglobulin G (IgG) were demonstrated between groups of mice that received monoclonal antibody-coated P. gingivalis versus those that received P. gingivalis alone by either route of immunization. Binding of monoclonal antibody 61BG1.3 to P. gingivalis prior to immunization did not influence the serum IgG subclass distribution. However, minor differences in subclass distribution were observed between the various routes of mucosal immunization. These results support the hypothesis that specific monoclonal antibody bound to a bacterial vaccine can alter the quality of the humoral immune response to that organism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 21:38:19