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Titolo:
Central but not peripheral glucocorticoid infusion in adrenalectomized male rats increases basal and substrate-induced insulinemia through a parasympathetic pathway
Autore:
Sainsbury, A; Wilks, D; Cooney, GJ;
Indirizzi:
St Vincents Hosp, Garvan Inst Med Res, Diabet Res Grp, Darlinghurst, NSW 2010, Australia St Vincents Hosp Darlinghurst NSW Australia 2010 rst, NSW 2010, Australia
Titolo Testata:
OBESITY RESEARCH
fascicolo: 4, volume: 9, anno: 2001,
pagine: 274 - 281
SICI:
1071-7323(200104)9:4<274:CBNPGI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROPEPTIDE-Y INFUSION; CORTICOTROPIN-RELEASING HORMONE; MESSENGER-RNA LEVELS; BODY-WEIGHT GAIN; FA FA RATS; GENE-EXPRESSION; ADIPOSE-TISSUE; PANCREATIC-POLYPEPTIDE; NERVOUS-SYSTEM; ZUCKER RATS;
Keywords:
atropine; hyperinsulinemia; pancreatic polypeptide; intracerebroventricular; dexamethasone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Sainsbury, A St Vincents Hosp, Garvan Inst Med Res, Diabet Res Grp, 384 Victoria St, Darlinghurst, NSW 2010, Australia St Vincents Hosp 384 Victoria St Darlinghurst NSW Australia 2010
Citazione:
A. Sainsbury et al., "Central but not peripheral glucocorticoid infusion in adrenalectomized male rats increases basal and substrate-induced insulinemia through a parasympathetic pathway", OBES RES, 9(4), 2001, pp. 274-281

Abstract

Objective: Glucocorticoids acting through the central nervous system are postulated to play a role in the hyperinsulinemia and increased adiposity ofobesity. We investigated the role of parasympathetic activation in glucocorticoid induced hyperinsulinemia. Research Methods and Procedures: Plasma pancreatic polypeptide (PP) levelswere used as an index of parasympathetic output. Insulinemia and plasma PPlevels were measured basally and after intravenous glucose injection (300 mg/kg) in adrenalectomized male rats infused with dexamethasone (7.5 mug/kgper day) intracerebroventricularly (ICV) or subcutaneously (SC) for 3 to 6days in the presence or absence of acute atropine blockade (1.0 mg/kg). Food intake was controlled between groups. Results: Compared with normal rats, adrenalectomy decreased white adipose tissue depot weights and leptinemia, and these were restored to normal values by ICV but not SC dexamethasone infusion. Adrenalectomy significantly reduced insulinemia below normal levels, which was restored by SC dexamethasone replacement. However, ICV dexamethasone replacement increased insulinemia of adrenalectomized rats to levels higher than normal control values (basal, 500 +/- 40 pM vs. 280 +/- 40 pM; 1-minute postglucose, 2500 +/- 180 pM vs. 1240 +/- 260 pM; p < 0.0001) and increased plasma PP levels, which werecorrelated with insulinemia. Atropine significantly reduced plasma insulinand PP to levels similar to normal controls but had no effect in any othergroup. Discussion: These data show that glucocorticoids act within the brain to increase insulinemia, most likely through activation of parasympathetic efferent fibers. Such an affect would contribute to the adipogenic effects of central glucocorticoids.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 12:32:54