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Titolo:
Differentiation between reactive gliosis and diffuse astrocytoma by in situ hybridization
Autore:
Wessels, PH; Hopman, AHN; Ummelen, MIJ; Krijne-Kubat, B; Ramaekers, FCS; Twijnstra, A;
Indirizzi:
Univ Hosp Maastricht, Dept Neurol, Res Inst Growth & Dev, GROW, NL-6202 AZMaastricht, Netherlands Univ Hosp Maastricht Maastricht Netherlands NL-6202 AZ icht, Netherlands Univ Hosp Maastricht, Dept Mol Cell Biol & Genet, NL-6202 AZ Maastricht, Netherlands Univ Hosp Maastricht Maastricht Netherlands NL-6202 AZ icht, Netherlands Univ Hosp Maastricht, Dept Pathol, NL-6202 AZ Maastricht, Netherlands UnivHosp Maastricht Maastricht Netherlands NL-6202 AZ icht, Netherlands
Titolo Testata:
NEUROLOGY
fascicolo: 9, volume: 56, anno: 2001,
pagine: 1224 - 1227
SICI:
0028-3878(20010508)56:9<1224:DBRGAD>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERPHASE CYTOGENETICS; P53 MUTATIONS; BIOPSIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Wessels, PH Univ Hosp Maastricht, Dept Neurol, Res Inst Growth & Dev, GROW, POB 5800, NL-6202 AZ Maastricht, Netherlands Univ Hosp Maastricht POB 5800 Maastricht Netherlands NL-6202 AZ
Citazione:
P.H. Wessels et al., "Differentiation between reactive gliosis and diffuse astrocytoma by in situ hybridization", NEUROLOGY, 56(9), 2001, pp. 1224-1227

Abstract

The authors examined the use of chromosomal analysis by in situ hybridization to differentiate between nonneoplastic reactive gliosis and astrocytomas in cases in which routine histology was inconclusive. Numerical chromosomal aberrations were found in 80% of low-grade astrocytoma specimens and in none of the reactive gliosis specimens. Aneusomic tumor cells were detectedin four of 13 stereotactic samples with an initially inconclusive tissue diagnosis, three of which were later diagnosed as astrocytoma. The in situ hybridization procedure may have additional value in the differential diagnosis of reactive gliosis versus low-grade astrocytoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 11:25:18