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Titolo:
Dopamine D2 receptors in the insular cortex and the personality trait of novelty seeking
Autore:
Suhara, T; Yasuno, F; Sudo, Y; Yamamoto, M; Inoue, M; Okubo, Y; Suzuki, K;
Indirizzi:
Natl Inst Radiol Sci, Div Adv Technol Med Imaging, Inage Ku, Chiba 2368555, Japan Natl Inst Radiol Sci Chiba Japan 2368555 Inage Ku, Chiba 2368555, Japan Tokyo Med & Dent Univ, Fac Med, Tokyo, Japan Tokyo Med & Dent Univ TokyoJapan ed & Dent Univ, Fac Med, Tokyo, Japan
Titolo Testata:
NEUROIMAGE
fascicolo: 5, volume: 13, anno: 2001,
pagine: 891 - 895
SICI:
1053-8119(200105)13:5<891:DDRITI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; HUMAN BRAIN; ENDOGENOUS DOPAMINE; BINDING COMPETITION; PARKINSONS-DISEASE; C-11 RACLOPRIDE; PET; DENSITY; MODEL; GENE;
Keywords:
PET; extrastriatal dopamine D2 receptor; novelty seeking; personality; TCI; insular cortex, [C-11]FLB 457;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Suhara, T Natl Inst Radiol Sci, Div Adv Technol Med Imaging, Inage Ku, 9-1Anagawa 4Chome, Chiba 2368555, Japan Natl Inst Radiol Sci 9-1 Anagawa 4 Chome Chiba Japan 2368555 an
Citazione:
T. Suhara et al., "Dopamine D2 receptors in the insular cortex and the personality trait of novelty seeking", NEUROIMAGE, 13(5), 2001, pp. 891-895

Abstract

Human personality has been considered to have a neurochemical. background. We examined the relation between extrastriatal dopamine D2 receptor binding in living human brain and the personality trait of novelty seeking that has been proposed to be related to dopaminergic function in the brain. We measured extrastriatal dopamine D2 receptors of 24 healthy young male subjects using [C-11]FLB 457 positron emission tomography. The personality trait of each subject was assessed by the Temperament and Character Inventory (TCI). Correlation of dopamine D2 receptor binding with novelty seeking was calculated using region-of-interest analysis and statistical parametric mapping based on the binding potential images generated using a reference tissue model. A significant negative correlation was observed between binding potential values and the novelty seeking scores on TCI in the right insular cortex. No significant correlation was observed in any other region. Our result indicates that there is a significant association between dopamine D2 receptor binding and the human novelty seeking trait in the right insular cortex. (C) 2001 Academic Press.

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Documento generato il 25/01/20 alle ore 19:02:18