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Titolo:
Gray matter-changes and correlates of disease severity in schizophrenia: Astatistical parametric mapping study
Autore:
Wilke, M; Kaufmann, C; Grabner, A; Putz, B; Wetter, TC; Auer, DP;
Indirizzi:
Max Planck Inst Psychiat, NMR, D-80804 Munich, Germany Max Planck Inst Psychiat Munich Germany D-80804 D-80804 Munich, Germany Max Planck Inst Psychiat, Suicide Study Grp, D-80804 Munich, Germany Max Planck Inst Psychiat Munich Germany D-80804 D-80804 Munich, Germany
Titolo Testata:
NEUROIMAGE
fascicolo: 5, volume: 13, anno: 2001,
pagine: 814 - 824
SICI:
1053-8119(200105)13:5<814:GMACOD>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; PREFRONTAL CORTEX; BRAIN; VOLUME; ABNORMALITIES; NEUROLEPTICS; CEREBELLUM; PSYCHOSES; CINGULATE; SYMPTOM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Wilke, M Max Planck Inst Psychiat, NMR, Kraepelinstr 10, D-80804 Munich, Germany Max Planck Inst Psychiat Kraepelinstr 10 Munich Germany D-80804
Citazione:
M. Wilke et al., "Gray matter-changes and correlates of disease severity in schizophrenia: Astatistical parametric mapping study", NEUROIMAGE, 13(5), 2001, pp. 814-824

Abstract

Voxel-based morphometry has recently been used successfully to detect graymatter volume reductions in schizophrenic patients. The aim of the presentstudy was to confirm the findings on gray-matter changes and to complementthese by applying the methodology to CSF-differences. Also, we wanted to determine whether a correlation exists between a clinically defined parameter of disease severity and brain morphology in schizophrenic patients. We investigated 48 schizophrenic patients and compared them with 48 strictly age- and sex-matched controls. High-resolution whole-brain MR-images were segmented and analyzed using SPM99. In a further analysis, the covariate effectof the global assessment of functioning-score (GAF) was calculated. Main findings were (i) left-dominant frontal, temporal, and insular GM-reductionsand (ii) GM-increases in schizophrenic patients in the right basal gangliaand bilaterally in the superior cerebellum; (iii) CSF-space increases in patients complementary to some GM-reductions; (iv) a correlation between theGAF-score and local GM-volume in the left inferior frontal and inferior parietal lobe of schizophrenic patients. This study confirms and extends someearlier findings on GM-reduction and detected distinct GM-increases in schizophrenic patients. These changes were corroborated by complementary CSF-increases. Most importantly, a correlation could be established between two particular gray matter-regions and the overall disease severity, with more severely ill patients displaying a local GM-deficit. These findings may be of potentially large importance for both the future interpretation and design of neuroimaging studies in schizophrenia and the further elucidation of possible pathophysiological processes occurring in this disease. (C) 2001 Academic Press.

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Documento generato il 15/07/20 alle ore 20:07:21