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Titolo:
Landmark-based morphometrics of the normal adult brain using MRI
Autore:
Free, SL; OHiggins, P; Maudgil, DD; Dryden, IL; Lemieux, L; Fish, DR; Shorvon, SD;
Indirizzi:
Inst Neurol, Natl Soc Epilepsy MRI Unit, Epilepsy Res Grp, London WC1N 3BG, England Inst Neurol London England WC1N 3BG sy Res Grp, London WC1N 3BG, England Univ Coll, Dept Anat & Dev Biol, London, England Univ Coll London England iv Coll, Dept Anat & Dev Biol, London, England Univ Nottingham, Dept Stat, Nottingham NG7 2RD, England Univ Nottingham Nottingham England NG7 2RD , Nottingham NG7 2RD, England
Titolo Testata:
NEUROIMAGE
fascicolo: 5, volume: 13, anno: 2001,
pagine: 801 - 813
SICI:
1053-8119(200105)13:5<801:LMOTNA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE IMAGES; HUMAN SENSORIMOTOR SYSTEM; HUMAN CEREBRAL-CORTEX; HUMAN MOTOR CORTEX; PLANUM TEMPORALE; CENTRAL SULCUS; MORPHOLOGICAL VARIATION; ANATOMICAL DIFFERENCES; STATISTICAL-ANALYSIS; ALZHEIMERS-DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Free, SL Inst Neurol, Natl Soc Epilepsy MRI Unit, Epilepsy Res Grp, Queen Sq, London WC1N 3BG, England Inst Neurol Queen Sq London England WC1N 3BG n WC1N 3BG, England
Citazione:
S.L. Free et al., "Landmark-based morphometrics of the normal adult brain using MRI", NEUROIMAGE, 13(5), 2001, pp. 801-813

Abstract

We describe the application of statistical shape analysis to homologous landmarks on the cortical surface of the adult human brain. Statistical shapeanalysis has a sound theoretical basis. Landmarks are identified on the surface of a 3-D reconstruction of the segmented cortical surface from magnetic resonance image (MRI) data. Using publicly available software (morphologika) the location and size dependence of the landmarks are removed and the differences in landmark distribution across subjects are analysed using principal component analysis. These differences, representing shape differences between subjects, can be visually assessed using wireframe models and transformation grids. The MRI data of 58 adult brains (27 female and 15 left handed) were examined. Shape differences in the whole brain are described which concern the relative orientation of frontal lobe sulci. Analysis of all116 hemispheres revealed a statistically significant difference (P < 0.001) between left and right hemispheres. This finding was significant for right- but not left-handed subjects alone. No other significant age, gender, handedness, or brain-size correlations with shape differences were found. (C)2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:16:30