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Titolo:
Maturation of widely distributed brain function subserves cognitive development
Autore:
Luna, B; Thulborn, KR; Munoz, DP; Merriam, EP; Garver, KE; Minshew, NJ; Keshavan, MS; Genovese, CR; Eddy, WF; Sweeney, JA;
Indirizzi:
Univ Pittsburgh, Neurobehav Studies Program, Pittsburgh, PA 15260 USA UnivPittsburgh Pittsburgh PA USA 15260 Program, Pittsburgh, PA 15260 USA Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA rgh, Dept Psychiat, Pittsburgh, PA USA Univ Pittsburgh, Dept Radiol, MR Res Ctr, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 Res Ctr, Pittsburgh, PA 15260 USA Univ Pittsburgh, Dept Neurosci, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 eurosci, Pittsburgh, PA 15260 USA Queens Univ, Dept Physiol, Kingston, ON K7L 3N6, Canada Queens Univ Kingston ON Canada K7L 3N6 siol, Kingston, ON K7L 3N6, Canada Carnegie Mellon Univ, Dept Stat, Pittsburgh, PA 15213 USA Carnegie Mellon Univ Pittsburgh PA USA 15213 at, Pittsburgh, PA 15213 USA
Titolo Testata:
NEUROIMAGE
fascicolo: 5, volume: 13, anno: 2001,
pagine: 786 - 793
SICI:
1053-8119(200105)13:5<786:MOWDBF>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; SPATIAL WORKING-MEMORY; FRONTAL EYE FIELD; NEURONAL-ACTIVITY; BASAL GANGLIA; ANTI-SACCADES; PRO-SACCADES; IN-VIVO; CORTEX; ACTIVATION;
Keywords:
inhibition; eye movements; cerebellum; neuroimaging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Luna, B Univ Pittsburgh, Neurobehav Studies Program, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 Pittsburgh, PA 15260 USA
Citazione:
B. Luna et al., "Maturation of widely distributed brain function subserves cognitive development", NEUROIMAGE, 13(5), 2001, pp. 786-793

Abstract

Cognitive and brain maturational changes continue throughout late childhood and adolescence. During this time, increasing cognitive control over behavior enhances the voluntary suppression of reflexive/impulsive response tendencies. Recently, with the advent of functional MRI, it has become possible to characterize changes in brain activity during cognitive development. In order to investigate the cognitive and brain maturation subserving the ability to voluntarily suppress context-inappropriate behavior, we tested 8-30 year olds in an oculomotor response-suppression task. Behavioral results indicated that adult-like ability to inhibit prepotent responses matured gradually through childhood and adolescence. Functional MRI results indicatedthat brain activation in frontal, parietal, striatal, and thalamic regionsincreased progressively from childhood to adulthood. Prefrontal cortex wasmore active in adolescents than in children or adults; adults demonstratedgreater activation in the lateral cerebellum than younger subjects. These results suggest that efficient top-down modulation of reflexive acts may not be fully developed until adulthood and provide evidence that maturation of function across widely distributed brain regions lays the groundwork for enhanced voluntary control of behavior during cognitive development. (C) 2001 Academic: Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:27:18