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Titolo:
Suppression of angiogenesis and therapy of human colon cancer liver metastasis by systemic administration of interferon-alpha
Autore:
Ozawa, S; Shinohara, H; Kanayama, H; Bruns, CJ; Bucana, CD; Ellis, LM; Davis, DW; Fidler, IJ;
Indirizzi:
Univ Texas, MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 tr, Dept Canc Biol, Houston, TX 77030 USA Univ Texas, MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 r, Dept Surg Oncol, Houston, TX 77030 USA
Titolo Testata:
NEOPLASIA
fascicolo: 2, volume: 3, anno: 2001,
pagine: 154 - 164
SICI:
1522-8002(200103/04)3:2<154:SOAATO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; RENAL-CELL CARCINOMA; NUDE-MICE; CLINICAL-APPLICATIONS; PANCREATIC-CARCINOMA; BLADDER-CARCINOMA; FACTOR RECEPTOR; ONCOLOGY-GROUP; EXPRESSION; TUMOR;
Keywords:
angiogenesis; apoptosis; interferon;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Fidler, IJ Univ Texas, MD Anderson Canc Ctr, Dept Canc Biol, 1515 HolcombeBlvd,Box 173, Houston, TX 77030 USA Univ Texas 1515 Holcombe Blvd,Box 173 Houston TX USA 77030 USA
Citazione:
S. Ozawa et al., "Suppression of angiogenesis and therapy of human colon cancer liver metastasis by systemic administration of interferon-alpha", NEOPLASIA, 3(2), 2001, pp. 154-164

Abstract

The purpose of this study was to determine whether systemic administrationof interferon-alpha (IFN-LU) can inhibit liver metastasis produced in nudemice by human colon cancer cells. KM12L4 (IFN-alpha -sensitive) or KM12L4 IFNR (IFN-alpha -resistant) cells were injected into the spleen of nude mice. Seven days later, the mice were treated with subcutaneous (s.c.) injections of IFN-alpha (70,000 units/week) at different dosing schedules (1, 2, or 7 times/week). Significant inhibition of tumor growth, vascularization and expression of basic fibroblast growth factor (bFGF) or matrix metalloproteinase-9 (MMP-9) mRNA and protein occurred in mice given daily injections of IFN-alpha. Kinetic analysis of therapy showed that daily s.c. administrations of 10,000 units of IFN-alpha induced apoptosis in liver metastasis-associated endothelial cells, followed by inhibition of tumor cell division and apoptosis of tumor cells. These data suggest that the antiangiogenic activity of IFN-alpha -2a depends on frequent administration of the optimal biologic dose.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:59:37