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Titolo:
Vascular differences detected by MRI for metastatic versus nonmetastatic breast and prostate cancer xenografts
Autore:
Bhujwalla, ZM; Artemov, D; Natarajan, K; Ackerstaff, E; Solaiyappan, M;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Radiol, Div MR Res,MR Oncol Sect, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 l Sect, Baltimore, MD 21205 USA
Titolo Testata:
NEOPLASIA
fascicolo: 2, volume: 3, anno: 2001,
pagine: 143 - 153
SICI:
1522-8002(200103/04)3:2<143:VDDBMF>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; CARCINOMA CELL-LINE; TUMOR ANGIOGENESIS; GD-DTPA; NUDE-MICE; ENHANCING AGENT; ATHYMIC MICE; HYPOXIA; VOLUME; PC-3;
Keywords:
vascular MRI; metastasis; invasion; breast and prostate cancer xenografts;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Bhujwalla, ZM Johns Hopkins Univ, Sch Med, Dept Radiol, Div MR Res,MR Oncol Sect, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 ore, MD 21205 USA
Citazione:
Z.M. Bhujwalla et al., "Vascular differences detected by MRI for metastatic versus nonmetastatic breast and prostate cancer xenografts", NEOPLASIA, 3(2), 2001, pp. 143-153

Abstract

Several studies have linked vascular density, identified in histologic sections, to "metastatic risk. " Functional information of the vasculature, notreadily available from histologic sections, can be obtained with contrast-enhanced MRI to exploit for therapy or metastasis prevention. Our aims wereto determine if human breast and prostate cancer xenografts preselected for differences in invasive and metastatic characteristics established correspondingly different Vascular Volume and permeability, quantified here with noninvasive MRI of the intravascular contrast agent albumin-GdDTPA. Tumor vascular volume and permeability of human breast and prostate cancer xenografts were characterized using MRI, Parallel studies confirmed the invasive behavior of these cell lines. Vascular endothelial growth factor (VEGF) expression in the cell lines was measured using ELISA and Western blots. Metastasis to the lungs was evaluated with spontaneous as well as experimental assay. Metastatic tumors formed vasculature with significantly higher permeability or vascular volume (P<.05, two-sided unpaired t test). The permeability profile matched VEGF expression. Within tumors, regions of high vascularVolume usually exhibited low permeability whereas regions of low vascular volume exhibited high permeability. We observed that although invasion was necessary, without adequate vascularization it was not sufficient for metastasis to occur.

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Documento generato il 21/01/21 alle ore 04:04:28