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Titolo:
Tumor cells express Fc gamma RI which contributes to tumor cell growth anda metastatic phenotype
Autore:
Nelson, MB; Nyhus, JK; Wilson, KIO; Barbera-Guillem, E;
Indirizzi:
BioCrystal Ltd, Westerville, OH 43082 USA BioCrystal Ltd Westerville OH USA 43082 al Ltd, Westerville, OH 43082 USA
Titolo Testata:
NEOPLASIA
fascicolo: 2, volume: 3, anno: 2001,
pagine: 115 - 124
SICI:
1522-8002(200103/04)3:2<115:TCEFGR>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
TYROSINE KINASE-ACTIVITY; SIGNAL-TRANSDUCTION; CROSS-LINKING; B-LYMPHOCYTES; CANCER; RECEPTOR; APOPTOSIS; PROLIFERATION; INHIBITION; RESPONSES;
Keywords:
B lymphocytes; tumor; cellular proliferation; Fc receptors; signal transduction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Barbera-Guillem, E BioCrystal Ltd, 575 McCorkle blvd, Westerville, OH 43082 USA BioCrystal Ltd 575 McCorkle blvd Westerville OH USA 43082
Citazione:
M.B. Nelson et al., "Tumor cells express Fc gamma RI which contributes to tumor cell growth anda metastatic phenotype", NEOPLASIA, 3(2), 2001, pp. 115-124

Abstract

High levels of circulating immune complexes containing tumor-associated antigens are associated with a poor prognosis for individuals with cancer. The ability of B cells, previously exposed to tumor-associated antigens, to promote both in vitro and in vivo tumor growth formed the rationale to evaluate the mechanism by which immune complexes may promote tumor growth. in elucidating this mechanism, Fc gamma RI expression by tumor cells was characterized by flow cytometry, polymerase chain reaction, and sequence analysis. Immune complexes containing shed tumor antigen and anti-shed tumor antigenAb cross-linked Fc gamma RI-expressing tumor cells, which resulted in an induction of tumor cell proliferation and of shed tumor antigen production. Use of selective tyrosine kinase inhibitors demonstrated that tumor cell proliferation induced by immune complex cross-linking of Fc gamma RI is dependent on the tyrosine kinase signal transduction pathway. A selective inhibitor of phosphatidylinositol -3 kinase also inhibited this induction of tumor cell proliferation. These findings support a role for immune complexes and Fc gamma RI expression by tumor cells in augmentation of tumor growth anda metastatic phenotype.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:35:42